Apparatus and method for imaging objects with wavefields

• US 20060084859A1
• Filed: 09/09/2005
• Published: 04/20/2006
• Est. Priority Date: 06/22/1995
• Status: Active Grant

• Current Assignee: Biotex Pharma Investments, LLC
• Original Assignee: Techniscan, Inc.
• Inventors: Johnson, Steven A., Berggren, Michael J., Wiskin, James, Borup, David T.
• Granted Patent: US 7,841,982 B2
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 8/00 Diagnosis using ultrasonic, sonic or infrasonic waves imaging of objects using sonar G01S15/00
• CPC Class Codes: A61B 8/0825 for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/463 characterised by displaying multiple images or images and diagnostic data on one display composite display in devices for short-range imaging with acoustic waves G01S7/52074
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties

Abstract

A transmission wave field imaging method, comprising the transmission of an incident wave field into an object, the incident wave field propagating into the object and, at least, partially scattering. Also includes the measuring of a wave field transmitted, at least in part, through an object to obtain a measured wave field, the measured wave field based, in part, on the incident wave field and the object. Additionally, the processing of the measured wave field utilizing a parabolic approximation reconstruction algorithm to generate an image data set representing at least one image of the object.

Claims

1. A transmission wave field imaging method, comprising:

transmitting an incident wave field into an object, the incident wave field propagating into the object and, at least, partially scattering;

measuring a wave field transmitted, at least in part, through the object to obtain a measured wave field, the measured wave field being defined, in part, by the incident wave field and the object; and

processing the measured wave field utilizing a parabolic approximation reconstruction algorithm to generate an image data set representing at least one image of the object.

2. The method of claim 1, wherein the parabolic approximation reconstruction algorithm calculates a predicted total wave field utilizing a single independent variable, the single independent variable representing scattering potential.

3. The method of claim 1, wherein the parabolic approximation reconstruction algorithm utilizes a parabolic binomial approximation.

4. The method of claim 1, wherein the object is tissue, the incident wave field is an acoustic wave field and the parabolic approximation reconstruction algorithm models acoustic wave propagation through the tissue.

5. The method of claim 1, wherein the parabolic approximation reconstruction algorithm models forward wave propagation of the incident wave field.

6. The method of claim 1, wherein the object is a breast scanner and the processing generates the image of a breast during a breast scan.

7. The method of claim 1, wherein the image represents quantitative estimates of a speed-of-sound associated with the object.

8. The method of claim 1, wherein the image represents quantitative estimates of an attenuation associated with the object.

9. The method of claim 1, wherein the incident wave field represents an ultrasound wave field and the method further comprises displaying the at least one image as at least two images co-displayed, the at least two images including a speed-of-sound image and an attenuation image.

10. The method of claim 1, wherein the incident wave field represents an ultrasound wave field and the method further comprises displaying the at least one transmissive image as at least two images co-displayed, the at least two images including a speed-of-sound image and an attenuation image.

11. The method of claim 1, wherein the incident wave field comprises at least one of acoustic energy, elastic energy, electromagnetic energy and microwave energy.

12. The method of claim 1, wherein the transmitting and receiving are performed by a transmitter and receiver, respectively, the method further comprising moving at least one of the transmitter and receiver with respect to the object.

13. The method of claim 1, further comprising repeating the transmitting and receiving at multiple slices within the object to generate a 3D volume of data.

14. The method of claim 1, further comprising displaying 2-D images representative of slices through the object.

15. The method of claim 1, further comprising displaying a 3-D image of at least a portion of the object.

16. The method of claim 1, further comprising:

obtaining speed-of-sound and attenuation values from the image data set, the speed-of-sound values corresponding to a speed of ultrasound wave fields through tissue, the attenuation values corresponding to an amount of attenuation of ultrasound wave fields propagating through the tissue.

17. The method of claim 1, further comprising:

constructing a speed-of-sound image from the measured wave field;

constructing an attenuation image from the measured wave field; and

displaying the speed-of-sound image and the attenuation image.

18. A transmission wave field imaging device, comprising:

a transmitter for transmitting an incident wave field into an object, the incident wave field propagating into the object and, at least, partially scattering;

a receiver measuring a total wave field transmitted, at least in part, through the object to obtain a measured wave field, the measured wave field being defined, in part, by the incident wave field and the object; and

a processing module processing the measured wave field utilizing a parabolic approximation reconstruction algorithm to generate an image data set representing at least one image of the object.

19. The device of claim 18, wherein the processor module comprises a plurality of processors operated in parallel.

20. The device of claim 18, wherein the processor module is implemented on one of a personal computer, a hand-held device, a multi-processor system and a network PC.

21. The device of claim 18, wherein the receiver is rotated about the object to obtain measured data at multiple receive positions around the object, the measured data defining the measured wave field.

22. The device of claim 18, further comprising a display for displaying an image based on the image data set as at least one of a speed of sound image and an attenuation image.

23. The device of claim 18, wherein at least one of the receiver and the transmitter includes transducer elements arranged in at least one of a circular array, a linear array, a 2D planar array and a checkerboard 2D array.

24. The device of claim 18, wherein the transmitter sequentially transmits first and second incident wave fields into the object having different first and second fundamental frequencies, respectively.

25. A transmission wave field imaging system, comprising:

a transmitter for transmitting an incident wave field into an object, the incident wave field propagating into the object and, at least, partially scattering;

a receiver measuring a total wave field transmitted, at least in part, through the object to obtain a measured wave field, the measured wave field being defined, in part, by the incident wave field, a scattering potential and the object, the measured wave field including at least one of speed of sound information and attenuation information characterizing the object;

a processing module for processing, on-site and in real-time, the measured wave field utilizing a parabolic approximation reconstruction algorithm to generate an image data set representing at least one image of the object, the image comprising pixel values based on at least one of the speed of sound information and the attenuation information characterizing the object; and

.

a display for displaying, on-site and in real-time, the image containing at least one of the speed of sound information and the attenuation information of the object.

26. The system of claim 25, wherein the system is a breast scanner and the processing module generates the image during a breast scan.

27. The system of claim 25, further comprising a phase detector joined to the receiver, the phase detector outputting real and imaginary signal components.

28. The system of claim 25, wherein the transmitter and receiver repeat the transmitting and receiving operations at multiple slices within the object to collect a 3D volume of data.

29. The system of claim 25, wherein the display displays 2-D images representative of slices through the object.

30. The system of claim 25, wherein the display displays a 3-D image of at least a portion of the object.

31. The system of claim 25, further comprising a movable carriage supporting the transmitter and receiver, the movable carriage rotating about an axis of a cylindrical chamber that is configured to receive the object.

32. The system of claim 25, further comprising a movable carriage supporting the transmitter and receiver, the movable carriage being vertically adjusted along an axis of a cylindrical chamber that is configured to receive the object.

33. The system of claim 25, further comprising a fluid tank configured to receive at least one of the object, the transmitter and receiver.