Implant delivery catheter system and methods for its use
First Claim
Patent Images
1. A method of delivery of a therapeutic agent to a depth within the myocardium including the steps of:
- providing a helical shaped controlled release structure having a therapeutic agent selected from the set of agents consisting of macromolecules, gene therapy preparation, microspheres and micelles;
penetrating the endocardium of the heart with the helical shaped controlled release structure attached to a tube or catheter;
implanting the helical shaped controlled release structure to a depth within the myocardium; and
delivering therapeutic agents to the heart tissue over time by diffusion, elution, osmosis, or hydrolysis from the implanted controlled release structure;
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Abstract
Catheter systems and methods for implanting helical or dart-like implants into the myocardium or other body tissue. The catheter system includes a helix for fixing the distal end of the catheter to the myocardium, an implant held by the helix, mechanisms for driving the fixation helix into the myocardium, and mechanisms for driving the implant into the myocardium, removing the fixation helix and leaving the implant behind. The implant may be coated, filled, or made of a drug or drug eluting compound, or drug delivery matrix of any composition.
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Citations
10 Claims
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1. A method of delivery of a therapeutic agent to a depth within the myocardium including the steps of:
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providing a helical shaped controlled release structure having a therapeutic agent selected from the set of agents consisting of macromolecules, gene therapy preparation, microspheres and micelles;
penetrating the endocardium of the heart with the helical shaped controlled release structure attached to a tube or catheter;
implanting the helical shaped controlled release structure to a depth within the myocardium; and
delivering therapeutic agents to the heart tissue over time by diffusion, elution, osmosis, or hydrolysis from the implanted controlled release structure;
- View Dependent Claims (2)
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3. A method of delivery of a therapeutic agent selected from the set consisting of macromolecule, gene therapy preparation, microspheres, or micelles to a region surrounding a tumor including the steps of:
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penetrating the interstitium around the tumor with a helical structure attached to a tube or catheter;
implanting a helical shaped controlled release structure to a depth within the body tissue; and
delivering therapeutic agents to the heart tissue over time by diffusion, elution, osmosis, or hydrolysis from the implanted controlled release structure. - View Dependent Claims (4)
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5. A catheter system comprising:
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an elongate flexible body having a proximal end and a distal end;
a disengageable distally located drug delivery depot, where the depot is a hollow structure with one or more apertures containing a therapeutic agent within its hollow structure;
a mechanism at the proximal end of the flexible body for disengaging said disengageable distally located drug depot; and
a fixation means on said disengageable distally located drug delivery depot that may be used within the body ducts and vasculature to implant drug delivery depots reservoir to a depth within an intended tissue, so that the depot is below the surface of the tissue. - View Dependent Claims (6, 7, 8, 9, 10)
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Specification