Medical devices for delivering a therapeutic agent and method of preparation
1 Assignment
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Accused Products
Abstract
A device useful for localized delivery of a therapeutic agent is provided. The device includes a structure including a porous polymeric material and an elutable therapeutic agent in the form of a solid, gel, or neat liquid, which is dispersed in at least a portion of the porous polymeric material. Methods for making a medical device having a blood-contacting surface is also provided. One method involves: providing a structure comprising a porous material; contacting the structure comprising a porous material with a concentrating agent to disperse the concentrating agent throughout at least a portion of the porous material; contacting the structure comprising a porous material and the concentrating agent with a solution of a therapeutic agent; and removing the therapeutic agent from solution within the porous material at the locations of the concentrating agent. Another method involves multiple immersion steps without the use of a concentrating agent.
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Citations
42 Claims
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1-25. -25. (canceled)
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26. A medical system comprising:
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a catheter having a dilatation balloon disposed on a distal end thereof; and
a deformable stent framework disposed on the dilatation balloon, wherein the stent includes at least one surface capable of contacting a site of vascular injury or trauma, the at least one surface comprising a porous material having dispersed therein an elutable therapeutic agent. - View Dependent Claims (27, 28, 29, 30, 31, 32, 34, 35, 36)
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37. A method for making an intravascular medical device, said method comprising the steps of:
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(a) providing a structure adapted for introduction into a blood vessel, the structure comprising a porous material;
(b) immersing said structure in a saturated solution of a therapeutic agent for a sufficient period of time to allow the solution to fill the porous material;
(c) removing the structure from the solution;
(d) drying the structure; and
(e) repeating steps (b) through (d) whereby to provide a therapeutic agent dispersed within the porous material. - View Dependent Claims (38, 39, 40, 41, 42)
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Specification