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Aptamer regulated nucleic acids and uses thereof

  • US 20060088864A1
  • Filed: 10/05/2005
  • Published: 04/27/2006
  • Est. Priority Date: 10/05/2004
  • Status: Active Grant
First Claim
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1. A nucleic acid comprising (i) a substrate sequence that can form a substrate for an extrinsic enzymatic activity, and (ii) an aptamer that binds to a ligand, wherein binding of the ligand to said aptamer causes a conformational change in the nucleic acid that alters the ability of said substrate sequence to form said substrate and/or alters the Km and/or Kcat of said substrate for the extrinsic enzymatic activity.

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