Medical implant with average surface charge density

• US 20060089709A1
• Filed: 10/21/2004
• Published: 04/27/2006
• Est. Priority Date: 10/21/2004
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Helmus, Michael N.
• Application Number:
  US10/970,264
• Publication Number:
  US 20060089709A1
• Time in Patent Office: Days
• US Class Current: 623/1.440
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2250/0001 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02

Abstract

A medical device for implantation into a host organism is disclosed. The device comprises a surface adapted for contact with body tissue of the host organism and an electrode disposed on at least a portion of the surface. Also the device comprises a power source in direct or indirect electrical communication with the electrode. The power source is capable of providing a current to the electrode to create an average surface charge density on the surface that is effective to promote the biocompatibility of the surface with the body tissue or create other desired biological effects.

Claims

1. A medical device for implantation into a host organism, the device comprising:

a surface adapted for contact with body tissue of the host organism;

an electrode disposed on at least a portion of the surface; and

a power source in direct or indirect electrical communication with the electrode, wherein the power source is capable of providing a current to the electrode to create an average surface charge density on the surface that is effective to promote the biocompatibility of the surface with the body tissue.

2. The device of claim 1 wherein the average surface charge density comprises a net negative charge of positive and negative charges.

3. The device of claim 1 wherein the average surface charge density comprises a net positive charge of positive and negative charges.

4. The device of claim 1 wherein the electrode is less than about 150 nm in length or less than about 150 nm in width.

5. The device of claim 1 wherein the device comprises a substantially cylindrical shape, and wherein the surface defines a boundary of the cylindrical shape.

6. The device of claim 1 wherein the device is a stent.

7. The device of claim 1 wherein the power source comprises an induction coil, a battery or a pick-up coil

8. The device of claim 7, wherein the power source comprises an induction coil capable of being tuned to a preselected frequency.

9. The device of claim 8 wherein the induction coil is in communication with a remote generator capable of generating an oscillating magnetic field at the preselected frequency, wherein the oscillating magnetic field is capable of creating a voltage across the coil.

10. The device of claim 1 wherein the average surface charge density is maintained by a direct current.

11. The device of claim 1 wherein the average surface charge density is maintained by an alternating current.

12. The device of claim 11 wherein the alternating current is offset by a direct current base line.

13. The device of claim 1 wherein the average surface charge density is greater than 5 μ

C/cm².

14. The device of claim 1 wherein the average charge density ranges from about 0.05 to about 500 μ

C/cm².

15. The device of claim 1 wherein the average surface charge density ranges from about 0.5 to about 50 μ

C/cm².

16. A medical device for implantation into a host organism, the device comprising:

a first surface adapted for contact with a surface of a body lumen, wherein the body lumen contains a fluid;

a second surface adapted for contact with the fluid;

an electrode disposed on at least a portion of the first or second surface; and

a power source in direct or indirect electrical communication with the electrode, wherein the power source is capable of providing a current to electrode to create an average surface charge density on the first or second surface that is effective to promote the biocompatibility of the first or second surface with the surface of the body lumen or the fluid.

17. The device of claim 16 wherein the average surface charge density comprises a net negative charge of positive and negative charges.

18. The device of claim 16 wherein the average surface charge density comprises a net positive charge of positive and negative charges.

19. The device of claim 16 wherein the electrode is less than about 150 nm in length or less than about 150 nm in width.

20. The device of claim 16 further comprising a controller disposed on the first or second surface, wherein the controller is in electrical communication with the power source and the electrode and wherein the controller is capable of controlling the current provided to the electrode.

21. The device of claim 16 wherein the electrode is disposed on the first surface and the average surface charge density is created on the first surface to promote the biocompatibility of the first surface with the surface of the body lumen.

22. The device of claim 16 wherein the electrode is disposed on the second surface and the average surface charge density is created on the second surface to promote the biocompatibility of the second surface with the fluid.

23. The device of claim 16 wherein the device is a stent and the first surface is an outer surface of the stent and the second surface is an inner surface of the stent.

24. The device of claim 16 wherein the average surface charge density is greater than 5 μ

C/cm².

25. The device of claim 16 wherein the average surface charge density ranges from about 0.05 to about 500 μ

C/cm².

26. The device of claim 16 wherein the average surface charge density is from about 0.5 to about 50 μ

C/cm².

27. The device of claim 16 wherein the power source comprises a battery, a pick-up coil or an induction coil.

28. The device of claim 16 wherein the power source comprises a pick-up coil disposed on the first surface of the device.

29. The device of claim 28 wherein the pick-up coil is inductively coupled to a primary coil located external to the host organism.

30. A stent comprising:

a surface adapted for contact with body tissue of a host organism;

an electrode disposed on at least a portion of the surface; and

a power source comprising an induction coil in direct or indirect electrical communication with the electrode, wherein the induction coil is capable of providing a current to the electrode to create an average surface charge density on the surface that is effective to promote the biocompatibility of the surface with the body tissue, and wherein the average surface charge density is greater than 5 μ

C/cm² and wherein the average surface charge density comprises a net negative charge of positive and negative charges.

31. A medical device for implantation into a host organism, the device comprising:

a surface adapted for contact with body tissue of the host organism;

an electrode disposed on at least a portion of the surface; and

a power source in direct or indirect electrical communication with the electrode, wherein the power source is capable of providing a current to the electrode to create an average surface charge density on the surface that is effective to produce a desired biological effect.

32. The device of claim 31 wherein the biological effect is to encourage thrombus formation, enhance inflammation or enhance tissue formation.

33. The device of claim 31 wherein the enhancing tissue formation comprises enhancing fibrous tissue formation.

34. The device of claim 31 wherein the average surface charge density comprises a net positive charge of positive and negative charges.

35. The device of claim 31 wherein the electrode is less than about 150 nm in length or less than about 150 nm in width.

36. The device of claim 31 wherein the device comprises a substantially cylindrical shape, and wherein the surface defines a boundary of the cylindrical shape.

37. The device of claim 31 wherein the device is a stent.

38. The device of claim 31 wherein the power source comprises an induction coil, a battery or a pick-up coil

39. The device of claim 38 wherein the power source comprises an induction coil capable of being tuned to a preselected frequency.

40. The device of claim 39 wherein the induction coil is in communication with a remote generator capable of generating an oscillating magnetic field at the preselected frequency, wherein the oscillating magnetic field is capable of creating a voltage across the coil.

41. The device of claim 31 wherein the average surface charge density is maintained by a direct current.

42. The device of claim 31 wherein the average surface charge density is maintained by an alternating current.

43. The device of claim 31 wherein the alternating current is offset by a direct current base line.

44. The device of claim 31 wherein the average surface charge density is greater than 5 μ

C/cm².

45. The device of claim 31 wherein the average surface charge density ranges from about 0.05 to about 500 μ

C/cm².

46. The device of claim 31 wherein the average surface charge density ranges from about 0.5 to about 50 μ

C/cm².

47. A method of promoting the biocompatibility of a medical device for implantation into a host organism, comprising:

(a) obtaining a medical device having a surface adapted for contact with body tissue of the host organism;

(b) disposing an electrode on at least a portion of the surface; and

(c) disposing a power source in direct or indirect electrical communication with the electrode, wherein the power source is capable of providing a current to the electrode to create an average surface charge density on the surface that is effective to promote the biocompatibility of the surface with the body tissue.