Process and compositions for synthetic calibration of bio-photonic scanners
First Claim
1. A method of making a synthetic dopant to provide Raman scattering corresponding to a compound of interest detectable non-invasively, non-destructively, in-vivo by a scanner, the method comprising:
- determining a characteristic bond existing in the compound and detectable by the scanner;
providing a base material;
providing a reactant effective to react with the base material to form a dopant containing the characteristic bond;
providing a carrier; and
distributing the dopant in the carrier at a concentration effective to mimic the response of the compound of interest when scanned by the scanner.
1 Assignment
0 Petitions
Accused Products
Abstract
A method, apparatus, and set of compositions are disclosed for calibrating a bio-photonic scanner. The scanner detects selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a computer, including processor and memory connecting to the scanner, including an illuminator to direct light nondestructively onto tissue in vivo, a detector to detect an intensity of a radiant response of the tissue to the light, and a probe to direct light onto the subject and receive a radiant response back into the detector. The apparatus is calibrated using a synthetic material to mimic the radiant response of live tissue, correcting for background fluorescence and elastic scattering. Dopants in a matrix of synthetic material mimic selected molecular structures of tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film powdered and mixed.
51 Citations
11 Claims
-
1. A method of making a synthetic dopant to provide Raman scattering corresponding to a compound of interest detectable non-invasively, non-destructively, in-vivo by a scanner, the method comprising:
-
determining a characteristic bond existing in the compound and detectable by the scanner;
providing a base material;
providing a reactant effective to react with the base material to form a dopant containing the characteristic bond;
providing a carrier; and
distributing the dopant in the carrier at a concentration effective to mimic the response of the compound of interest when scanned by the scanner. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A method of calibrating a scanner illuminating tissue in vivo, non-destructively, and non-invasively to detect a Raman scattering response thereto, the method comprising:
-
forming a matrix material pigmented to provide a fluorescence response corresponding to that of tissue in response to the scanner;
forming a dopant providing a Raman scattering response corresponding to that of tissue;
mixing the matrix material and dopant to form a standard;
evaluating the standard for a Raman scattering response thereof;
diluting the standard with additional matrix material; and
ceasing dilution at a pre-determined value of Raman scattering response of the standard.
-
Specification