Light waveguide and fluorescent sensor using the light waveguide

• US 20060093262A1
• Filed: 10/26/2005
• Published: 05/04/2006
• Est. Priority Date: 11/01/2004
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: Matsumoto, Atsushi, Imuta, Shuuji
• Granted Patent: US 7,181,096 B2
• Time in Patent Office: Days
• US Class Current: 385/31
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B

Abstract

A light waveguide includes: a light introducing portion for introducing light coming from a light source into a waveguide main body; a light radiating surface for radiating the light introduced through the light introducing portion to the hydrogel side; a light transmitting surface which is disposed opposite to and in parallel to the light radiating surface and through which external light incident from the light radiating surface is transmitted to the exterior; a light separation portion, which provided on a surface in a region ranging from the light introducing portion to the light radiating surface and the light transmitting surface, reflecting only totally reflected components of the light introduced through the light introducing portion; an irregular reflection portion provided on the light transmitting surface to change the reflection angle on the light transmitting surface of the light reflected by the light separation portion; and a mirror portion provided at a position opposite to the light introducing portion.

Claims

1. A light waveguide comprised of a light transmitting material, said light waveguide comprising:

a light introducing portion for introducing light coming from a light source;

a light radiating surface for radiating the light introduced through said light introducing portion;

a light transmitting surface which is opposed to said light radiating surface and through which at least a portion of external light incident from said light radiating surface is transmitted to the exterior;

an irregular reflection portion provided on said light transmitting surface to change the reflection angle of light on said light transmitting surface; and

a light separation portion provided on a surface in a region ranging from said light introducing portion to said light radiating surface and said light transmitting surface, said light separation portion having an absorption layer formed of a material having a refractive index lower than the refractive index of said light transmitting material and higher than the refractive index of a material in contact with said light transmitting surface.

2. The light waveguide according to claim 1, satisfying the relationships of n1>

n2+0.01 and n2>

n3+0.01, where n1 is the refractive index of said light transmitting material, n2 is the refractive index of said absorption layer, and n3 is the refractive index of said material in contact with said light transmitting surface.

3. The light waveguide according to claim 1, having the relationship of the following formula (1), and t1 in the formula (1) is greater than 1:

X=μ

t1×

L×

Tan(Sin<sup>−

1</sup>(n2/n1)) 

 

(1),

where L is the thickness of said light waveguide, and X is the length from the light transmitting surface and said light radiating surface to said light introducing portion.

4. The light waveguide according to claim 1, wherein said absorption layer is formed of an amorphous fluoro-resin containing 0.1 to 10 mass % of carbon black.

5. The light waveguide according to claim 1, wherein said irregular reflection portion comprises:

a particulate mixed transparent layer in which particulates different in refractive index from a transparent material higher in refractive index than said light transmitting material are mixed in said transparent material; and

a reflection layer which is provided so as to hide said particulate mixed transparent layer from the exterior and which does not transmit but reflect light.

6. The light waveguide according to claim 1, wherein said irregular reflection portion comprises:

at least one recessed portion provided at a portion on said light transmitting surface; and

a reflection portion provided so as to hide said recessed portion from the exterior;

said recessed portion provided at a position excluding the inside of a waveguide formed at an angle b from an end portion of a light reflecting portion relative to a line perpendicular to said light transmitting surface, where b is the minimum incidence angle of the light being guided on said light transmitting surface.

7. The light waveguide according to claim 6, wherein said recessed portion is in a roughly cylindrical shape with a diameter of 1 to 50 μ

m and a depth of 1 to 50 μ

m.

8. The light waveguide according to claim 6, wherein at least two said recessed portions are provided, and said at least two recessed portions are covered by one reflection portion.

9. The light waveguide according to claim 8, wherein said at least two recessed portions are each in a roughly cylindrical shape with a diameter of 1 to 50 μ

m and a depth of 1 to 50 μ

m.

10. The light waveguide according to claim 6, wherein said recessed portion is filled with a mixed material obtained by mixing a transparent material higher in refractive index than said light transmitting material with particulates different in refractive index from said transparent material.

11. The light waveguide according to claim 1, wherein said light radiating surface, said light transmitting surface, said light separation portion, and said light introducing portion are provided in a waveguide main body formed of a transparent material;

and

the other portion of said waveguide main body than said light radiating surface, said light transmitting surface, said light separation portion, and said light introducing portion is covered by a reflective material which does not transmit but reflect light.

12. The light waveguide according to claim 1, wherein said light separation portion and said light transmitting surface further have a transparent layer lower in refractive index than said light transmitting material.

13. The light waveguide according to claim 1, wherein a plurality of said irregular reflection portions are provided on said light transmitting surface, and the minimum distance between the adjacent irregular reflection portions is within two times the distance between said light transmitting surface and said light radiating surface.

14. A fluorescent sensor comprising:

a light waveguide as set forth in claim 1;

a light source for radiating an excitation beam to a light introducing portion of said light waveguide;

an indicator layer provided in close contact with said light radiating surface of said light waveguide and comprising a hydrogel containing fluorescent indicator molecules which show a variation in fluorescent characteristics by reversibly bonding with an analyte; and

a photo-detector provided at a position opposite to said light transmitting surface of said light waveguide for converting fluorescent light from said indicator layer into an electrical signal.

15. The fluorescent sensor according to claim 14, wherein

said light waveguide, said light source, and said indicator layer are covered by a housing which contains them in the inside thereof and holds the inside thereof in a liquid-tight condition;

and

said light waveguide is disposed in said housing with said light radiating surface directed outwards.

16. The fluorescent sensor according to claim 14, wherein said fluorescent sensor is embedded in a living body for measuring a specified analyte in said living body.