Polymer coating for medical devices
First Claim
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1. A coating for a medical device having a body fluid-contacting surface for contacting blood, other body fluids and the like, the coating comprising:
- a polymerized silane derivative covalently bonded to the surface of a medical device, said polymerized silane derivative containing hydroxyl or amino functional groups;
a lactone polymer covalently bonded to the functional groups of the polymerized silane derivative via in-situ ring opening polymerization; and
at least one poly(lactide-co-caprolactone) copolymer layer deposited on the bonded lactone polymer layer.
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Abstract
Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of poly(lactide-co-caprolactone) copolymer on the bonded lactone. Biologically active agents may be disposed with the poly(lactide-co-caprolactone) copolymer layers. Such coated surfaces may be useful in medical devices, in particular stents.
110 Citations
26 Claims
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1. A coating for a medical device having a body fluid-contacting surface for contacting blood, other body fluids and the like, the coating comprising:
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a polymerized silane derivative covalently bonded to the surface of a medical device, said polymerized silane derivative containing hydroxyl or amino functional groups;
a lactone polymer covalently bonded to the functional groups of the polymerized silane derivative via in-situ ring opening polymerization; and
at least one poly(lactide-co-caprolactone) copolymer layer deposited on the bonded lactone polymer layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for coating a medical device comprising:
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(a) reacting the surface of a medical device with a silane-based activating reagent to form a polymerized silane derivative covalently bonded to the surface of the medical device, said polymerized silane derivative containing hydroxyl or other functional groups that can be transformed into hydroxyl groups;
(b) reacting the device of step (a) with at least one lactone monomer in the presence of a metal catalyst to form a lactone polymer covalently bonded to the polymerized silane derivative by in-situ grafting ring opening polymerization initiated by the functional groups of the polymerized silane derivative; and
(c) treating the device of step (b) with a poly(lactide-co-caprolactone) copolymer solution and subsequently removing the solvent to deposit a layer of the polymer adherent to the covalently bonded lactone polymer layer. - View Dependent Claims (15, 16, 17, 18)
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19. A medical device having a coating over a body fluid-contacting surface of the medical device for contacting blood, other body fluids and the like, wherein the coating comprises:
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a polymerized surface-activating layer covalently secured to the body fluid-contacting surface of the medical device, said activating layer containing hydroxyl or amino functional groups;
a lactone polymer covalently bonded to the functional groups of the polymerized silane derivative via in-situ ring opening polymerization; and
at least one poly(lactide-co-caprolactone) copolymer deposited on the bonded lactone polymer layer. - View Dependent Claims (20, 21, 22)
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23. A method of reducing cell proliferation in a mammal comprising providing to the mammal a medical device having a coating over a body fluid-contacting surface of the medical device for contacting blood, other body fluids and the like, wherein the coating comprises:
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a polymerized surface-activating layer covalently secured to the body fluid-contacting surface of the medical device, said activating layer containing hydroxyl or amino functional groups;
a lactone polymer covalently bonded to the silane derivative via in-situ ring opening polymerization; and
at least one poly(lactide-co-caprolactone) copolymer deposited on the bonded lactone polymer layer. - View Dependent Claims (24, 25, 26)
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Specification