Fluid occluding devices and methods

• US 20060095065A1
• Filed: 09/26/2005
• Published: 05/04/2006
• Est. Priority Date: 09/24/2004
• Status: Abandoned Application

• Current Assignee: LightLab Imaging, Inc. (Abbott Laboratories Incorporated)
• Original Assignee: LightLab Imaging, Inc. (Abbott Laboratories Incorporated)
• Inventors: Petersen, Christopher L., Lee, Christopher, Nakamatsu, Tetsuya, Tanimura, Tetsuaki, Khoune, Oudomsith
• Application Number:
  US11/235,692
• Publication Number:
  US 20060095065A1
• Time in Patent Office: Days
• US Class Current: 606/194
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector

Abstract

In one aspect, the invention relates to a method of occluding blood in a blood vessel during the imaging of a portion of the blood vessel. The method includes the steps of selecting an inflatable element such that diameter of the inflated inflatable element is greater than the diameter of the blood vessel being imaged, introducing the inflatable element into the blood vessel and underinflating the inflatable element such that the vessel wall is not substantially deformed by the inflatable element, the inflatable element substantially occluding the blood vessel to reduce imaging distortion resulting from vessel fluids.

Claims

1. A method of occluding blood in a blood vessel, having a vessel wall, during imaging of a portion of the blood vessel, comprising the steps of:

selecting an inflatable element such that diameter of the inflated inflatable element is greater than the diameter of the blood vessel being imaged;

introducing the inflatable element into the blood vessel; and

underinflating the inflatable element such that the vessel wall is not substantially deformed by the inflatable element, the inflatable element substantially occluding the blood vessel to reduce imaging distortion resulting from vessel fluids.

2. The method of claim 1 wherein the inflatable element comprises an expandable membrane.

3. The method of claim 1 wherein portions of the surface of the expandable membrane comprises folds when contacting the vessel wall.

4. The method of claim 1 wherein the inflatable element comprises a balloon.

5. The method of claim 1 further comprising the step of flushing the blood vessel with a fluid in a direction retrograde to a direction of normal blood flow.

6. A fluid occluding device, the device comprising:

an inflatable catheter and an imaging system to improve imaging quality by substantially blocking intra-vessel fluids,

the inflatable catheter comprising a balloon portion having a vessel contacting surface, wherein the balloon portion is oversized in relation to the vessel of interest.

7. The fluid occluding device of claim 6 wherein the balloon portion has a diameter that ranges from about 2 mm to about 4 mm.

8. The fluid occluding device of claim 6 wherein the inflation pressure of the balloon portion ranges from about 150 mbar to about 750 mbar.

9. The fluid occluding device of claim 6 wherein the vessel contacting surface comprises folds when in an underinflated state.

10. The fluid occluding device of claim 6 wherein the inflatable element comprises a hydrophobic coating applied to the vessel contacting surface.

11. A balloon catheter system, the system comprising:

a balloon connected to an inflation lumen, and

a combined flushing and imaging lumen extending distal to the balloon,

at least one coaxial exit aperture to the imaging lumen, and

a plurality of exit apertures along the imaging lumen, wherein the balloon operating pressures are substantially below 1 atmosphere.

12. The balloon catheter system of claim 11 wherein the plurality of exit apertures direct the flush flow at an angle retrograde to the normal blood flow.

13. The balloon catheter system of claim 11 wherein the portion of the imaging lumen distal to the balloon is adapted to be atraumatic to blood vessels.

14. The balloon catheter system of claim 11 wherein at least some of the exit apertures are orientated such that ejected flush solution is substantially retrograde to normal blood flow.

15. The balloon catheter system of claim 11 wherein the flush imaging lumen has several exit apertures arranged both longitudinally and circumferentially around the lumen to increase the effectiveness of the flush solution.

16. The balloon catheter system of claim 11 wherein the balloon is adapted to keep the combined flushing and imaging lumen substantially optically clear at least in a vessel segment proximate to the balloon.

17. The balloon catheter system of claim 11 wherein the exit apertures along the imaging lumen are adapted to direct flush solution against the wall of the inflated balloon to further increase the turbulence of the flush solution to improve mixing with and clearing of residual arterial blood.

18. The balloon catheter system of claim 11 wherein the flush imaging lumen provides stabilizing support for an imaging optical fiber.

19. The balloon catheter system of claim 11 wherein an OCT channel is included in at least one of the balloon, catheter, or both.

21. The method of claim 19 wherein the inflatable element is non-compliant or semi-compliant.

22. The method of claim 19 further comprising the step of controlling the volume of the inflatable element such that trauma to the vessel wall is substantially reduced.

23. The method of claim 19 wherein the portion of the vessel is imaged using an optical coherence tomography probe disposed in the vessel.

24. The method of claim 19 wherein the inflatable element comprises a hydrophobic coating.

20. A method of imaging a portion of a vessel having a vessel wall, the method comprising the steps of:

introducing an inflatable element having a volume within the vessel;

imaging the vessel wall while fluid is flowing through the vessel;

increasing the volume of the inflatable element incrementally such that image distortion effects caused by the fluid are substantially reduced without distorting the vessel.