Multichannel electrode and methods of using same
First Claim
1. A system comprising an interfacing connector for connecting to a multichannel electrode comprising a plurality of channels, at least one channel comprising an impedance suitable for recording and at least one channel suitable for stimulating, said connector comprising:
- a housing comprising, a first end and a second end, said first end for connecting to a device for communicating with said multichannel electrode, said second end for receiving said multichannel electrode;
a wall defining a lumen for receiving said multichannel electrode and comprising a plurality of contact points, wherein there is at least one contact point for each channel of said multichannel electrode, and wherein each contact point can transmit an electrical signal to the channel or receive an electrical signal from the channel.
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Accused Products
Abstract
The invention provides a multichannel electrode (“MC electrode”) which can perform multiple functions such as recording, stimulating and lesioning simultaneously or sequentially upon a single insertion into a target site. In one aspect, the MC electrode further provides imaging and drug delivery capabilities. The invention also provides interface connectors for connecting the MC electrode to external units such as data acquisition and/or stimulation systems. Although the MC electrode and associated connectors and system(s) provide an optimal way to perform deep brain surgical procedures, the MC electrode and associated connectors and system(s) are useful generally in any technique which relies on recording, activating, and/or inhibiting electrical signals produced by cells.
99 Citations
40 Claims
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1. A system comprising an interfacing connector for connecting to a multichannel electrode comprising a plurality of channels, at least one channel comprising an impedance suitable for recording and at least one channel suitable for stimulating, said connector comprising:
a housing comprising, a first end and a second end, said first end for connecting to a device for communicating with said multichannel electrode, said second end for receiving said multichannel electrode;
a wall defining a lumen for receiving said multichannel electrode and comprising a plurality of contact points, wherein there is at least one contact point for each channel of said multichannel electrode, and wherein each contact point can transmit an electrical signal to the channel or receive an electrical signal from the channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of monitoring the activity of one or more cells at a target site by recording electrical potentials of the one or more cells and/or modulating the activity of one or more cells, comprising bringing a multichannel (MC) electrode in electrical proximity to the one or more cells,
wherein said multichannel electrode comprises a plurality of electrode channels disposed thereon, wherein at least one of said channels has an impedance suitable for recording an electrical signal from a cell and wherein at least one other channel has an impedance suitable for electrical stimulation of a cell, and recording the activity of the one or more cells using said at least one channel with an impedance suitable for recording.
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31. A method for acute treatment of one or more cells with abnormal electrical activity, comprising:
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bringing a multichannel electrode in electrical proximity to one or more cells;
wherein said multichannel electrode comprises a plurality of electrode channels disposed thereon, wherein at least one of said channels has an impedance suitable for recording an electrical signal from a cell and wherein at least one other channel has an impedance suitable for electrical stimulation of a cell, localizing target cells in need of such treatment by identifying abnormal electrical activity using said at least one channel of said multichannel electrode comprising an impedance suitable for recording;
normalizing said abnormal electrical activity by delivering at least one stimulus from said at least one channel of said multichannel electrode comprising an impedance suitable for stimulating; and
removing said multichannel electrode from electrical proximity of said one or more cells.
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32. A method for chronic treatment of cells with abnormal electrical activity, comprising:
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bringing a multichannel electrode in proximity to one or more cells;
wherein said multichannel electrode comprises a plurality of electrode channels disposed thereon, wherein at least one of said channels has an impedance suitable for recording an electrical signal from a cell and wherein at least one other channel has an impedance suitable for electrical stimulation of a cell, localizing target cells in need of such treatment by identifying abnormal electrical activity using said at least one channel of said multichannel electrode comprising an impedance suitable for recording;
normalizing said abnormal electrical activity by delivering at least one stimulus from said at least one channel of said multichannel electrode comprising an impedance suitable for stimulating; and
maintaining the position of the electrode with respect to said one or more cells, monitoring the activity of said one or more cells, and stimulating the cells as necessary to maintain normalized electrical activity.
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33. A method for regulating drug delivery to a target site, comprising:
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bringing a multichannel electrode in electrical proximity to one or more cells at a target site being contacted with a drug;
wherein said multichannel electrode comprises a plurality of electrode channels disposed thereon, wherein at least one of said channels has an impedance suitable for recording an electrical signal from a cell and wherein at least one other channel has an impedance suitable for electrical stimulation of a cell, identifying abnormal electrical activity of cells at said target site using said at least one channel of said multichannel electrode comprising an impedance suitable for recording; and
changing the amount of drug provided to said target site. - View Dependent Claims (34)
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35. A method of fabricating a multichannel electrode, said method comprising the steps of:
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a) providing a non-planar backbone;
b) coating said non-planar backbone with an electrically conductive material; and
c) laser micro-machining a plurality of channels into said electrically conductive material;
wherein at least one channel comprises an impedance suitable for recording electrical activity of a cell, and wherein at least one channel comprises an impedance suitable for stimulating the electrical activity of a cell.
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36. A method of fabricating fabricating a multichannel electrode, said method comprising the steps of:
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a) providing a first non-planar backbone comprising a lumen;
b) coating said non-planar backbone with an electrically conductive material;
c) laser micro-machining a plurality of channels into said electrically conductive material;
d) providing a second non-planar backbone within said lumen of said first non-planar backbone, said second non-planar backbone coated with an electrically conductive material and comprising a plurality of electrode channels machined thereon;
wherein at least one channel of said multichannel electrode comprises an impedance suitable for recording electrical activity of a cell, and wherein at least one channel comprises an impedance suitable for stimulating the electrical activity of a cell; and
(e) placing said second backbone within said lumen of said first backbone.
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37. An interfacing connector for interfacing a multichannel electrode with one or more external devices,
wherein said multichannel electrode comprises a plurality of electrode channels disposed thereon, wherein at least one of said channels has an impedance suitable for recording an electrical signal from a cell and wherein at least one other channel has an impedance suitable for electrical stimulation of a cell, and wherein said one or more external devices selected from the group consisting of an amplifier, a suction device, a data acquisition system, a drive device, microdrive device, a processor, a light source, an oscilloscope, a detector, a fluid delivery pump, an amplifier, filter, a power supply, an implantable stimulator and/or recording device, and an interfacing cable.
Specification