Analyte recognition system

• US 20060096860A1
• Filed: 11/10/2004
• Published: 05/11/2006
• Est. Priority Date: 11/10/2004
• Status: Abandoned Application

• Current Assignee: Clinical Data, Inc. (Abbvie Incorporated)
• Original Assignee: Clinical Data, Inc. (Abbvie Incorporated)
• Inventors: Stein, Israel Mayer, Giesen, Gerardus Williebrordus, Rao, Jagan Mohan, Driver, Richard Dennis
• Application Number:
  US10/985,315
• Publication Number:
  US 20060096860A1
• Time in Patent Office: Days
• US Class Current: 204/409
• CPC Class Codes: G01N 27/333 Ion-selective electrodes or membranes glass electrodes G01N27/36

Abstract

An analyte recognition system uses an array (16) of ion-selective electrode (ISE) sensors, each sensitive to a different ion in a downstream flow path (32) therethrough to a coupling (30) which provides a ground or bias electrode. Another flow path (34) is upstream through an ISE sensor (26) which provides a reference electrode and the coupling. The coupling has a flow path, provided by a sidearm, to an outlet (40) going to a drain (35) for both the upstream and downstream flow paths. The upstream flow path reference electrode is a conduit for a reference fluid, and measurements from the other electrodes are made with respect to the reference electrode. Contamination and permanent poisoning of certain of the electrodes in the downstream path may occur if reversal of the flow were to take place, or if the reference fluid flowing in the upstream path were to flow into the downstream path. Reversal of flow is prevented by inclusion of a one-way valve, desirably a duckbill valve (75) in the coupling in the downstream path to the sidearm. Poisoning of the ISE sensors is prevented because the duckbill valve reduces the likelihood of a reversal of the normal downstream flow and reduces flow of the reference fluid in the upstream direction through the array of ion-selective electrodes.

Claims

1. In an array of chemical sensors, through different ones of which fluids under test flow in opposite directions through a coupling to an outlet, the improvement comprising a one-way valve in said coupling between said sensor downstream in the flow path in one of said opposite directions for enabling the flow in said one direction to said outlet and inhibiting the flow in the other of said opposite directions into said sensor in the downstream flow path thereby preventing flow through at least one of said different sensors in said upward direction into said one sensor and precluding contamination of said one sensor and which does not diminish the accuracy of the measurement.

2. The invention according to claim 1 wherein said coupling is a block having a T passageway with a cross-leg of said passage to said outlet and a first passage to said one and said second passage to said another of said different sensors, said one-way valve being in said first passage disposed to enable flow therethrough in said downstream direction and inhibiting flow from said second leg into said first leg in said upstream direction.

3. The invention according to claim 2 wherein said one-way valve is a duck-bill valve having a flexible closure collar tapering in said downstream direction so that pressurized flow is enabled through said closure in said downstream direction and said closure blocks flow therethrough in said upstream direction.

4. The invention according to claim 3 wherein said sensors are electrochemical sensors, said one sensor is responsive to a compound in a sample in said downstream flow and said other sensor is a reference sensor responsive to a reference compound in said upstream flow.

5. The invention according to claim 4 wherein said sensors are modules containing ion-selective electrodes via which said flow of said sample and reference fluid pass.

6. The invention according to claim 6 wherein a plurality of said ion-selective electrode modules are selective to different ions and are sequentially connected in said array to said coupling, and said other sensor is a reference electrode.

7. The invention according to claim 6 wherein said ion selective electrode modules are respectively responsive to K, Na, Cl, and CO₂ ions and all of said sensors and said coupling are assembled together in a pack, with the CO₂ responsive electrode module as the last electrode in the downstream flow path.

8. A system comprising:

an array of ion-selective electrodes coupled to a tubing for receiving a sample fluid;

a reference ion-selective electrode; and

a ground electrode having two ports, a drain coupled to each of said ports, a one-way valve in a first of said ports for preventing back flow through said tubing, which is coupled to said first of said ports, and a second of said ports provides receiving of a reference fluid.

9. The system according to claim 8 further comprising a reference ion-selective electrode, in communication with said second of said ports, for receiving said reference fluid.

10. A coupling comprising a block having a conduit providing a fluid path forming a T between sides of said block and a junction inside said block, and a one-way valve in said conduit between said junction and one of said sides of said block.

11. The coupling according to claim 10 wherein said coupling provides an electrode, said block being of conductive material and a connection for an electric circuit to said block.

12. The coupling according to claim 11 wherein said coupling is a ground electrode and said connection is to a point of reference potential of said circuit.

13. The coupling according to claim 10 wherein said one-way valve is a duckbill valve.