Median filter for liquid chromatography-mass spectrometry data
First Claim
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1. Apparatus for characterizing a chemical sample, comprising:
- a chromatography instrument operatively associated with a mass spectrometer; and
a processor comprising means for obtaining a chromatogram comprising signal data and noise date from a series of mass spectra of said sample produced by said chromatography instrument and said mass spectrometer, said processor further comprising means for applying a median filter to said chromatogram to remove at least some of said noise data, thereby producing a filtered chromatogram.
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Abstract
High-intensity, spiked noise is reduced in chromatography-mass spectrometry data by applying a nonlinear filter such as a moving median filter to the data. The filter is applied to individual mass chromatograms, plots of ion abundance versus retention time for each detected mass-to-charge ratio, and the filtered chromatograms are combined to form a filtered total ion current chromatogram. Standard linear filters are not effective for reducing noise in liquid chromatography-mass spectrometry (LC-MS) data because they assume a normal distribution of noise. LC-MS noise, however, is not normally distributed.
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Citations
10 Claims
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1. Apparatus for characterizing a chemical sample, comprising:
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a chromatography instrument operatively associated with a mass spectrometer; and
a processor comprising means for obtaining a chromatogram comprising signal data and noise date from a series of mass spectra of said sample produced by said chromatography instrument and said mass spectrometer, said processor further comprising means for applying a median filter to said chromatogram to remove at least some of said noise data, thereby producing a filtered chromatogram. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification