Multiplexed mass spectrometer

• US 20060097157A1
• Filed: 03/29/2005
• Published: 05/11/2006
• Est. Priority Date: 03/29/2004
• Status: Active Grant

• Current Assignee: Purdue Research Foundation (Purdue University)
• Original Assignee: Purdue Research Foundation (Purdue University)
• Inventors: Cooks, Robert G., Ouyang, Zheng
• Granted Patent: US 7,157,699 B2
• Time in Patent Office: Days
• US Class Current: 250/290
• CPC Class Codes: H01J 49/009 Spectrometers having multiple channels, parallel analysis
• CPC Class Codes: H01J 49/4205 Device types

Abstract

A multiplexed mass spectrometer system includes an array of mass analyzers and a data acquisition system. Each mass analyzer is associated with one or more data channels, and the data acquisition system selectively reduces the number of data channels through combinations of particular channels to define data acquisition modes for the molecular characterization of the samples. The selective reduction in channels can be achieved, for example by software manipulation of the acquired data or by combining the detected signals.

Claims

1. A multiplexed mass spectrometer for characterizing the molecular structure of samples, the system comprising:

an array of mass analyzers, each mass analyzer being associated with one or more data channels; and

a data acquisition system that selectively reduces the number of data channels through combinations of particular channels to define data acquisition modes for the molecular characterization of the samples.

2. The spectrometer of claim 1 wherein the selective reduction in channels is achieved by software manipulation of the acquired data.

3. The spectrometer of claim 1 wherein the selective reduction in channels is achieved by combining detected signals from the mass analyzers.

4. The spectrometer of claim 1 wherein the selective reduction in channels is achieved by grouping ions by type before mass analysis.

5. The spectrometer of claim 1 wherein the data acquisition system compares data between grouped channels.

6. The spectrometer of claim 1 wherein fast screening is used to identify targeted compounds in a group of samples.

7. The spectrometer of claim 1 wherein the acquisition modes are used to monitor the intensities of the targeted compounds for a group of samples.

8. The spectrometer of claim 1 wherein the mass analyzers are rectilinear ion traps.

9. The spectrometer of claim 8 wherein two-direction radial ejection is used to implement two data acquisition modes simultaneously.

10. The spectrometer of claim 8 wherein axial ejection is used to implement additional data acquisition modes.

11. The spectrometer of claim 8 wherein x, y radial ejection and axial ejection are used to implement multiple data acquisition modes

12. The spectrometer of claim 8 wherein the array is used to allow ion transfer to achieve ion recombination modes.

13. The spectrometer of claim 1 wherein the mass analyzers are selected from the group consisting of ion traps, rectilinear ion traps, quadrupole ion traps, and cylindrical ion traps.

14. The spectrometer of claim 13 wherein ions are redistributed by mass-selectivity or non-mass-selectivity transferring between the mass analyzers.

15. The spectrometer of claim 1 further comprising an array of ionizers which ionize multiple samples.

16. The spectrometer of claim 15 wherein the array of mass analyzers is an array of multiple types of mass analyzers and the array off ionizers is an array of multiple type of ionizers.

17. A multiplexed mass spectrometer system comprising:

a microfluidic handling system which collects samples from an array of samples;

an array of ionizers which ionize multiple samples collected by the microfluic handling system;

an array of ion traps, each ion trap being associated with one or more data channels, each data channel being associated with particular groups of the samples; and

a data acquisition system that selectively reduces the number of data channels through combinations of particular channels to define data acquisition modes.

18. A method for characterizing the molecular structure of samples comprising:

directing ions associated with the samples with an array of mass analyzers, each mass analyzer being associated with one or more data channels; and

selectively reducing the number of data channels through combinations of particular channels to define data acquisition modes for molecular characterization of the samples.

19. The method of claim 18 wherein the selective reduction in channels is achieved by software manipulation of the acquired data.

20. The method of claim 18 wherein the selective reduction in channels is achieved by combining detected signals from the mass analyzers.

21. The method of claim 18 wherein the selective reduction in channels is achieved by grouping ions by type before mass analysis.

22. The method of claim 18 further comprising comparing data between grouped channels.

23. The method of claim 18 further comprising fast screening to identify targeted compounds in a group of samples.

24. The method of claim 18 wherein the mass analyzers are rectilinear ion traps.