Methods of diagnosing cardiovascular disease
First Claim
1. A method of diagnosing or aiding in the diagnosis of a vascular condition in an individual, the method comprising (a) determining the level of a resistin gene product in a biological sample obtained from the individual;
- and (b) comparing the level with a control level, wherein if the level determined in (a) is greater than the control level, the individual is diagnosed as having the vascular condition.
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Accused Products
Abstract
The invention relates to predicting which individuals are at risk of developing atherosclerotic vascular disease, and once having disease, which individuals are at risk of experiencing plaque rupture which, depending on the site of the plaque, could produce myocardial infarction, stroke, critical limb ischemia, or other vascular event. The invention further relates to methods of diagnosing and aiding in the diagnosis of vascular conditions such as atherosclerosis, premature coronary artery disease and coronary artery disease, by detecting a resistin gene product in an individual. The invention further relates to methods of predicting, and aiding in predicting, the likelihood that an individual will experience a vascular event, such as but not limited to, a myocardial infarction, acute coronary syndrome, stroke, transient ischemic attack (TIA), or critical limb ischemia.
17 Citations
40 Claims
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1. A method of diagnosing or aiding in the diagnosis of a vascular condition in an individual, the method comprising
(a) determining the level of a resistin gene product in a biological sample obtained from the individual; - and
(b) comparing the level with a control level, wherein if the level determined in (a) is greater than the control level, the individual is diagnosed as having the vascular condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for predicting the likelihood that an individual will develop a vascular condition, the method comprising
(a) determining the level of a resistin gene product in a biological sample obtained from the individual; - and
(b) comparing the level with a control level, wherein if the level determined in (a) is greater than the control level, the individual is said to have increased likelihood of experiencing the vascular event. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification