Method and apparatus for determining tissue viability

• US 20060100489A1
• Filed: 06/25/2003
• Published: 05/11/2006
• Est. Priority Date: 06/25/2002
• Status: Abandoned Application

• Current Assignee: Giucon Inc.
• Original Assignee: IntelliDx, Inc.
• Inventors: Pesach, Benny, Balberg, Michal
• Application Number:
  US10/519,024
• Publication Number:
  US 20060100489A1
• Time in Patent Office: Days
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: G01K 11/22 using measurement of acoustic effects
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids
• CPC Class Codes: G01N 2291/015 Attenuation, scattering
• CPC Class Codes: G01N 2291/02466 Biological material, e.g. blood
• CPC Class Codes: G01N 2291/02475 Tissue characterisation
• CPC Class Codes: G01N 2291/02881 Temperature
• CPC Class Codes: G01N 2291/101 one transducer
• CPC Class Codes: G01N 29/2418 using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046
• CPC Class Codes: G01N 29/32 Arrangements for suppressing undesired influences, e.g. temperature or pressure variations , compensating for signal noise

Abstract

A tissue viability monitor (TVM) for determining viability of a biological tissue comprising: at least one light source controllable to illuminate the tissue with light that generates photoacoustic waves therein; at least one acoustic transducer that generates signals responsive to the photoacoustic waves; and a controller that receives the signals and processes the signals to determine at least one characteristic of the tissue and a measure of viability responsive to the determined at least one characteristic.

Claims

1. A tissue viability monitor (TVM) for determining viability of a biological tissue comprising:

at least one light source controllable to illuminate the tissue with light that is absorbed by an analyte in the tissue to generate photoacoustic waves therein;

at least one acoustic transducer that generates signals responsive to the photoacoustic waves;

means for generating a temperature difference between temperature of the tissue and an ambient temperature of surrounding tissue; and

a controller adapted to control the means for generating a temperature difference in the tissue and to control the light source to illuminate the tissue with light absorbed by at least one analyte in the tissue and wherein the controller processes the signals generated by the at least one transducer to determine concentration of at least one analyte in the tissue and to determine temperature in the tissue and therefrom a relaxation time during which the temperature difference relaxes to zero and uses the concentration and relaxation time to provide a measure of viability.

2. A TVM in accordance with claim 1 wherein the controller processes the signals to determine locations of sources of the photoacoustic waves within the tissue.

3. A TVM in accordance with claim 2 wherein the locations of sources of photoacoustic waves are determined with a resolution equal to or better than about 100 micrometers.

4. A TVM in accordance with claim 2 wherein the locations of sources of photoacoustic waves are determined with a resolution equal to or better than about 50 micrometers.

5. A TVM in accordance with claim 2 wherein the locations of sources of photoacoustic waves are determined with a resolution equal to or better than about 20 micrometers.

6. A TVM in accordance with claim 1 wherein the at least one analyte is a plurality of analytes.

7. A TVM in accordance claim 1 wherein the at least one analyte comprises the redox state cytochrome a,a₃.

8. A TVM in accordance claim 1 wherein the at least one analyte comprises Hydrogen ions.

9. A TVM in accordance with claim 1 wherein the at least one analyte comprises hemoglobin.

10. A TVM in accordance with claim 1 wherein the at least one analyte comprises oxygenated hemoglobin.

11. A TVM in accordance with claim 1 wherein the means for generating a temperature difference comprises an acoustic transducer, which the controller controls to transmit acoustic waves to the tissue that generate the temperature difference.

12. A TVM in accordance with claim 1 wherein the controller determines temperature of the tissue during generation of the temperature difference to monitor the generation of the temperature difference.

13. A TVM in accordance with claim 12 wherein the controller controls the means for generating a temperature difference responsive to the determined temperature.

14. A TVM in accordance with claim 1 wherein to determine the relaxation time the light source illuminates the tissue with light at a wavelength at which light is absorbed by water to generate photoacoustic waves in the tissue and the controller uses the signals generated by the at least one transducer to determine temperature of water in the tissue and thereby of the tissue.

15. A TVM according to claim 1 and comprising a catheter having a probe end that is positioned in a neighborhood of or in contact with the tissue to determine tissue viability and wherein the light source comprises an optic fiber having an optic end located at the probe end from which optic end light that illuminates the tissue is radiated.

16. A TVM in accordance with claim 15 wherein the at least one acoustic transducer comprises at least one acoustic transducer mounted in the probe end of the catheter.

17. A tissue viability monitor (TVM) for determining viability of a biological tissue comprising:

at least one light source controllable to illuminate the tissue with light that is absorbed by an analyte in the tissue to generate photoacoustic waves therein;

at least one transmitting acoustic transducer controllable to transmit waves that are incident on the tissue;

at least one sensing acoustic transducer that generates signals responsive to the photoacoustic waves and waves from the incident waves that are reflected by the tissue;

means for generating a temperature difference between temperature of the tissue and an ambient temperature of surrounding tissue; and

a controller that processes the signals responsive to photoacoustic waves to determine concentration of at least one analyte in the tissue and the signals responsive to reflected waves to determine temperature of the tissue and therefrom a relaxation time during which the temperature difference relaxes to zero and wherein the controller uses the concentration and relaxation time to provide a measure of viability.

18. A TVM according to claim 17 wherein the characteristic is a frequency shift of the scattered acoustic waves relative to a fundamental acoustic frequency of the structure of the tissue.

19. A method of determining viability of a biological tissue comprising:

generating a temperature difference between temperature of the tissue and an ambient temperature of surrounding tissue;

illuminating the tissue with light that is absorbed by at least one analyte in the tissue to generate photoacoustic waves therein;

determining concentration of an analyte in the tissue responsive to the photoacoustic waves;

determining a relaxation time during which the temperature difference relaxes to zero responsive to the photoacoustic waves; and

providing a measure of viability responsive to the concentration and the relaxation time.

20. A method of determining viability of a biological tissue comprising:

illuminating the tissue with light that is absorbed by at least one analyte in the tissue to generate photoacoustic waves therein;

determining concentration of at least one analyte in the tissue responsive to the photoacoustic waves;

generating a temperature difference between temperature of the tissue and an ambient temperature of surrounding tissue;

transmitting acoustic waves that are incident on and reflected by the tissue;

determining a relaxation time during which the temperature difference relaxes to zero responsive to the reflected acoustic waves; and

providing a measure of viability responsive to the concentration and the relaxation time.