System and method for monitoring blood glucose levels using an implantable medical device
First Claim
1. A method of monitoring blood glucose levels using an implantable medical device, the method comprising:
- detecting patient cardiac signals;
detecting a first feature from the cardiac signals, the first feature known to exhibit a substantially bimodal response as a function of blood glucose levels;
detecting at least one additional feature from the cardiac signals, the additional feature known to exhibit a substantially monotonic response as a function of blood glucose levels; and
deriving a blood glucose level based on a combination of the first feature and the at least one additional feature.
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Abstract
T-wave amplitude and QT interval are derived from patient cardiac signals. Then blood glucose levels are determined based on a combination of the T-wave amplitude and the QT interval. By using a combination of both T-wave-based and QT interval-based signals, blood glucose levels can be reliably detected throughout a wide range of blood glucose levels. Once the blood glucose level has been detected, the implanted device compares the blood glucose level against upper and lower acceptable bounds and appropriate warning signals are generated if the level falls outside the bounds. In one example, wherein an implantable insulin pump is additionally provided, the pump is controlled based on the detected blood glucose level to maintain glucose levels within an acceptable range. A calibration technique is also provided for determining patient-specific parameters for use in the detection of blood glucose levels.
40 Citations
12 Claims
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1. A method of monitoring blood glucose levels using an implantable medical device, the method comprising:
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detecting patient cardiac signals;
detecting a first feature from the cardiac signals, the first feature known to exhibit a substantially bimodal response as a function of blood glucose levels;
detecting at least one additional feature from the cardiac signals, the additional feature known to exhibit a substantially monotonic response as a function of blood glucose levels; and
deriving a blood glucose level based on a combination of the first feature and the at least one additional feature. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An implantable medical device comprising:
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a cardiac signal detection unit operative to detect a first feature of a cardiac signal that exhibits a substantially bimodal response as a function of blood glucose levels and at least one additional feature of the cardiac signal that exhibits a substantially monotonic response as a function of blood glucose levels; and
a processor operative to derive a blood glucose level based on a combination of the first feature and the at least one additional feature. - View Dependent Claims (9, 10)
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11. An implantable medical device comprising:
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a detection unit operative to detect a QT interval of a cardiac signal; and
a processor operative to derive a corrected QT interval based on the detected QT interval and to derive a blood glucose level based on the corrected QT interval. - View Dependent Claims (12)
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Specification