Methods and systems of achieving hemodynamic control through neuromodulation

• US 20060100667A1
• Filed: 09/12/2005
• Published: 05/11/2006
• Est. Priority Date: 01/20/2000
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Machado, Andre, Machado, Sandra, Rezai, Ali
• Granted Patent: US 7,865,237 B2
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02

Abstract

Method of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation. The method comprises applying a therapy signal to a celiac ganglion, a celiac plexus, a splanchnic nerve, or any combination thereof and adjusting the signal to effectuate treatment. The present invention also provides methods of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation by transluminal modulation of the celiac ganglion, the celiac plexus, the splanchnic nerve.

Claims

1. A method of treating shock comprising:

applying a therapy signal to a celiac plexus, a celiac ganglion, a splanchnic nerve or any combination thereof;

sensing a hematological parameter associated with the shock and generating a sensor signal; and

adjusting the therapy signal in response to the sensor signal to treat the shock.

2. The method of claim 1, wherein the therapy signal is an electrical signal.

3. The method of claim 1, wherein the therapy signal is a chemical signal.

4. The method of claim 1, wherein the therapy signal is applied to a celiac ganglion.

5. The method of claim 4, wherein the therapy signal is applied to a left celiac ganglion, a right celiac ganglion, or both.

6. The method of claim 1, wherein the therapy signal is applied to the splanchnic nerve.

7. The method of claim 6, wherein the therapy signal is applied to the greater splanchnic nerve, the lesser splanchnic nerve, the lowest thoracic splanchnic nerve, or any combination thereof.

8. The method of claim 1, wherein the therapy signal is applied to a left splanchnic nerve, a right splanchnic nerve, or both.

9. The method of claim 1, wherein the therapy signal is applied to the celiac plexus, the celiac ganglion, the splanchnic nerve or any combination thereof for a period of less than ten days.

10. A method of treating shock comprising:

inserting a therapy delivery device into a lumen of the body;

advancing the therapy delivery device to a point in the lumen adjacent to a celiac plexus, a celiac ganglion or a splanchnic nerve; and

activating the therapy delivery device to apply a therapy signal to the celiac plexus, celiac ganglion or splanchnic nerve to treat the shock.

11. The method of claim 10, wherein the lumen is a blood vessel.

12. The method of claim 11, wherein the blood vessel is an artery.

13. The method of claim 11, wherein the blood vessel is a vein.

14. The method of claim 13, wherein the vein is the inferior vena cava.

18. The method of claim 13, wherein controlling the mobilization of the splanchnic circulation comprises decreasing the mobilization of the splanchnic circulation into active circulation to decrease an effective circulating volume of blood.

19. A method of treating congestive heart failure comprising the method of claim 18.

15. A method of controlling the mobilization of splanchnic circulation comprising:

applying a therapy signal to a celiac plexus, a celiac ganglion, a splanchnic nerve or any combination thereof;

sensing a hematological parameter associated with the splanchnic circulation and generating a sensor signal; and

adjusting the therapy signal in response to the sensor signal to control the mobilization of the splanchnic circulation.

16. The method of claim 15, wherein controlling the mobilization of the splanchnic circulation comprises increasing the mobilization of the splanchnic circulation into active circulation to increase an effective circulating volume of blood.

17. A method of treating shock comprising the method of claim 16.

20. A method of controlling the mobilization of splanchnic circulation comprising:

inserting a therapy delivery device into a lumen of the body;

advancing the therapy delivery device to a point in the lumen adjacent to a celiac plexus, a celiac ganglion or a splanchnic nerve; and

activating the therapy delivery device to apply a therapy signal to the celiac plexus, celiac ganglion or splanchnic nerve to control the mobilization of the splanchnic circulation.

21. The method of claim 20, wherein the lumen is a blood vessel.

22. The method of claim 21, wherein the blood vessel is an artery.

23. The method of claim 21, wherein the blood vessel is a vein.

24. The method of claim 23, wherein the vein is the inferior vena cava.