Inhalable formulations for treating pulmonary hypertension and methods of using same
First Claim
1. An inhalable formulation for the treatment of pulmonary hypertension, said formulation comprising a therapeutically effective amount of a hypertension reducing agent, wherein said pulmonary hypertension reducing agent is at least one of an ACEI, ARB, beta-blocker, calcium-channel blocker or vasodilator and wherein said formulation is suitable for administration via inhalation to a mammal in need thereof.
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Abstract
The present invention is directed to an inhalable formulation for the treatment of pulmonary hypertension in a mammal (e.g., humans), wherein the formulation comprises at least one hypertension reducing agent, including but not limited to an angiotensin converting enzyme inhibitor, angiotensin receptor blocker, beta-blocker, calcium-channel blocker or vasodilator, or any combination thereof. The formulations of the present invention may be a solution or suspension, and preferably are suitable for administration via nebulization. The present invention is also directed to a method and kit for treating a mammal suffering from pulmonary hypertension.
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Citations
44 Claims
- 1. An inhalable formulation for the treatment of pulmonary hypertension, said formulation comprising a therapeutically effective amount of a hypertension reducing agent, wherein said pulmonary hypertension reducing agent is at least one of an ACEI, ARB, beta-blocker, calcium-channel blocker or vasodilator and wherein said formulation is suitable for administration via inhalation to a mammal in need thereof.
- 27. A method of treating pulmonary hypertension in a mammal, said method comprising the step of administering to said mammal a formulation comprising a therapeutically effective amount of a hypertension reducing agent, wherein said hypertension reducing agent is at least one of an ACEI, ARB, beta-blocker, calcium-channel blocker or vasodilator, and wherein said formulation is suitable for administration via inhalation.
- 38. A kit for treating pulmonary hypertension in a mammal, said kit comprising an prepackaged formulation comprising a therapeutically effective amount of a hypertension reducing agent, wherein said hypertension reducing agent is at least one of an ACEI, ARB, beta-blocker, calcium-channel blocker or vasodilator, and wherein said formulation is suitable for administration via nebulization to a mammal in need thereof.
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41. An inhalable formulation for the treatment of pulmonary hypertension, said formulation comprising about 0.2-10.0 mg/ml, Enalaprilat, (s-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-praline dehydrate, about 2.0-10.0 mg/ml Sodium Chloride, Sodium Hydroxide and water, wherein said formulation is suitable for administration via nebulization to a mammal in need thereof.
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42. An inhalable formulation for the treatment of pulmonary hypertension, said formulation comprising about 1.0-10.0 mg/ml, Atenolol (Benzeneacetamide, 4-[2-hydroxy-3-(1-methylethyl)amino propoxy], about 2.0-10.0 mg/ml Sodium Chloride, Sodium Citrate, Citric Acid and water, wherein said formulation is suitable for administration via nebulization to a mammal in need thereof.
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43. An inhalable formulation for the treatment of pulmonary hypertension, said formulation comprising about 0.1-3.0 mg/ml Epoprostenol, about 0.2-2.0 mg/ml, Span 85 and water, wherein said formulation is suitable for administration via nebulization to a mammal in need thereof.
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44. An inhalable formulation for the treatment of pulmonary hypertension, said formulation comprising about 0.1-10.0 mg/ml Treprostinil sodium, about 2.0-10.0 mg/ml, Sodium Chloride, Sodium Hydroxide, Citric Acid and water, wherein said formulation is suitable for administration via nebulization to a mammal in need thereof.
Specification