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Materials and procedures for the purification of cells

  • US 20060105399A1
  • Filed: 12/20/2005
  • Published: 05/18/2006
  • Est. Priority Date: 11/08/1996
  • Status: Active Grant
First Claim
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1. A method for isolating a target cell from a sample, said method comprising i) contacting said sample with a conductive immunopolymer matrix, wherein said conductive immunopolymer matrix comprises:

  • a) a first immunopolymer layer comprising a polyheteroaromatic polymer and an Fc receptor entrapped within said polymer, wherein a first antibody is bound to said Fc receptor in said first polymer; and

    b) a second immunopolymer layer comprising a polyheteroaromatic polymer and an Fc receptor entrapped within said polymer, wherein a second antibody is bound to said Fc receptor in said second polymer and said second antibody binds to a determinant or antigen that said first antibody does not bind; and

    wherein said first and second immunopolymer layers further comprise a cell monitoring system, wherein said cell monitoring system comprises horseradish peroxidase and glucose oxidase entrapped within said first and second immunopolymers; and

    wherein said first or second antibody binds to a molecule expressed on said target cell, thereby isolating said target cell from said sample.

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