Compositions and methods for enhancement of transdermal analyte flux
First Claim
1. A method of determining the concentration of an analyte in a mammalian subject using a monitoring system comprising an iontophoretic sampling device having first and second iontophoretic electrodes, said method comprising:
- providing a current to the first and second iontophoretic electrodes of the sampling device in an amount sufficient to effect the extraction of said analyte through the mammalian subject'"'"'s skin, i) into a hydrogel composition comprising a) a hydrophilic compound capable of forming a gel in the presence of water, b) an electrolyte, a phosphate buffer present at a concentration of between about 125 mM and about 500 mM, and c) a pH of between about pH 6.5 to about pH 8.5, and ii) to a catalytic surface of a first sensing electrode, wherein (i) a first surface of said hydrogel is in contact with a tissue surface of the mammalian subject, and (ii) a second surface of said hydrogel is in contact with the first iontophoretic electrode and the first sending electrode;
providing a potential to the first sensing electrode in an amount sufficient to drive electrochemical detection of said analyte or an analyte-related chemical signal;
measuring electrical current generated by the electrochemical detection at the electrode; and
correlating the measured current to a concentration or amount of analyte in the mammalian subject.
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Abstract
The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making/manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.
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Citations
6 Claims
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1. A method of determining the concentration of an analyte in a mammalian subject using a monitoring system comprising an iontophoretic sampling device having first and second iontophoretic electrodes, said method comprising:
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providing a current to the first and second iontophoretic electrodes of the sampling device in an amount sufficient to effect the extraction of said analyte through the mammalian subject'"'"'s skin, i) into a hydrogel composition comprising a) a hydrophilic compound capable of forming a gel in the presence of water, b) an electrolyte, a phosphate buffer present at a concentration of between about 125 mM and about 500 mM, and c) a pH of between about pH 6.5 to about pH 8.5, and ii) to a catalytic surface of a first sensing electrode, wherein (i) a first surface of said hydrogel is in contact with a tissue surface of the mammalian subject, and (ii) a second surface of said hydrogel is in contact with the first iontophoretic electrode and the first sending electrode;
providing a potential to the first sensing electrode in an amount sufficient to drive electrochemical detection of said analyte or an analyte-related chemical signal;
measuring electrical current generated by the electrochemical detection at the electrode; and
correlating the measured current to a concentration or amount of analyte in the mammalian subject. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification