Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods

• US 20060106430A1
• Filed: 11/12/2004
• Published: 05/18/2006
• Est. Priority Date: 11/12/2004
• Status: Abandoned Application

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Inventors: Fowler, Brad, Gliner, Bradford Evan
• Application Number:
  US10/987,118
• Publication Number:
  US 20060106430A1
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient'"'"'s skull and implanting an electrode device within the patient'"'"'s skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient'"'"'s brain.

Claims

1. A method for treating a brain disorder, comprising:

identifying a target neural structure within a patient'"'"'s skull;

implanting an electrode device within the patient'"'"'s skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure; and

stimulating the target neural structure by applying an electrical signal to the at least one electrical contact.

2. The method of claim 1 wherein implanting the electrode device includes implanting the electrode device adjacent to a vascular structure.

3. The method of claim 1 wherein implanting the electrode device includes implanting the electrode device adjacent to at least one of a major blood vessel, a sinus, a vascular trunk and a vascular branch.

4. The method of claim 1 wherein implanting the electrode device includes positioning the at least one contact between, along, across, or adjacent to at least one of a fissure, recess and groove of the patient'"'"'s brain.

5. The method of claim 1 wherein implanting the electrode device includes positioning the at least one contact between, along, across, or adjacent to at least one of a fissure, recess and groove of the patient'"'"'s brain into which the target neural structure projects.

6. The method of claim 1 wherein identifying a target neural structure includes identifying a portion of at least one of the auditory cortex, the somatosensory cortex, and Heschl'"'"'s gyri.

7. The method of claim 1 wherein identifying a target neural structure includes identifying a portion of at least one of the primary auditory cortex, the secondary auditory cortex, and the secondary somatosensory cortex.

8. The method of claim 1 wherein implanting the electrode device includes positioning the at least one contact proximate to the auditory cortex.

9. The method of claim 1 wherein stimulating the target neural structure includes treating an auditory dysfunction of the patient.

10. The method of claim 1 wherein stimulating the target neural structure includes stimulating the auditory cortex and the somatosensory cortex, simultaneously or alternately.

11. The method of claim 1 wherein stimulating the target neural structure includes treating a tinnitus condition of the patient.

12. The method of claim 1 wherein stimulating the target neural structure includes stimulating a neuronal cell that is elongated in a direction transverse to the axis.

13. The method of claim 1 wherein implanting the electrode device includes implanting the electrode device at an epidural location.

14. The method of claim 1 wherein implanting the electrode device includes implanting the electrode device at a subdural location.

15. The method of claim 1 wherein applying an electrical signal includes applying a unipolar signal.

16. The method of claim 1 wherein applying an electrical signal includes applying a bipolar signal.

17. The method of claim 1 wherein implanting the electrode device includes positioning a first contact adjacent to and on one side of a cranial vascular structure, and positioning a second contact adjacent to and on an opposite side of the cranial vascular structure.

18. The method of claim 1 wherein implanting the electrode device includes positioning the at least one contact proximate to the Sylvian fissure.

19. The method of claim 1 wherein applying an electrical signal includes alternating between a bipolar and a unipolar electrical signal.

20. The method of claim 1, further comprising varying at least one parameter according to which the electrical signal is applied while the electrode device is implanted beneath the patient'"'"'s skull.

21. The method of claim 1 wherein applying an electrical signal includes transmitting the electrical signal from a first conductive structure located external to the patient'"'"'s scalp, via the patient'"'"'s scalp to a second conductive structure located beneath the patient'"'"'s scalp.

22. The method of claim 1 wherein implanting an electrode assembly includes implanting multiple electrode assemblies and wherein the method further comprises coupling the multiple electrode assemblies to a single pulse generator.

23. A method for treating tinnitus, comprising:

identifying a target auditory neural population projecting into the Sylvian fissure of a patient'"'"'s brain;

implanting an electrode device within the patient'"'"'s skull proximate to the Sylvian fissure so that an axis that is generally normal to the skull and passes through at least one electrical contact of the electrode device is offset from the target auditory neural population; and

stimulating the target auditory neural population by applying an electrical signal to the at least one electrical contact.

24. The method of claim 23 wherein stimulating the target neural auditory population includes stimulating a first neural structure and affecting the functioning of a second neural structure that communicates with the first neural structure.

25. The method of claim 23 wherein stimulating the target auditory neural population includes stimulating at least a portion of the primary auditory cortex.

26. The method of claim 23 wherein stimulating the target auditory neural population includes stimulating at least a portion of the somatosensory cortex.

27. The method of claim 23 wherein stimulating the target auditory neural population includes stimulating at least a portion of Heschl'"'"'s gyri.

28. The method of claim 23 wherein stimulating the target auditory neural population includes stimulating at least a portion of at least one of the primary auditory cortex, the secondary auditory cortex, and the secondary somatosensory cortex.

29. The method of claim 23 wherein applying an electrical signal includes applying a unipolar signal.

30. The method of claim 23 wherein applying an electrical signal includes applying a bipolar signal.

31. A method for treating a brain disorder, comprising:

implanting an electrode device within a patient'"'"'s skull so that at least one electrical contact of the device is positioned at least 0.5 mm from the superior sagittal sinus; and

stimulating a neural structure located directly inferior to the superior sagittal sinus by applying an electrical signal to the at least one electrical contact.

32. The method of claim 31 wherein stimulating a neural structure includes stimulating a neuronal cell that is elongated in a direction transverse to an axis passing through the electrode device and extending generally normal to the patient'"'"'s skull.

33. The method of claim 31 wherein implanting the electrode device includes implanting the electrode device at an epidural location.

34. The method of claim 31 wherein implanting the electrode device includes implanting the electrode device at a subdural location.

35. The method of claim 31 wherein applying an electrical signal includes applying a unipolar signal.

36. The method of claim 31 wherein applying an electrical signal includes applying a bipolar signal

37. The method of claim 31 wherein applying an electrical signal includes alternating between a bipolar and a unipolar electrical signal.

38. The method of claim 31, further comprising varying at least one parameter according to which the electrical signal is applied while the electrode device is implanted beneath the patient'"'"'s skull.

39. The method of claim 31 wherein applying an electrical signal includes transferring the electrical signal from a first conductive structure located external to the patient'"'"'s scalp, via the patient'"'"'s scalp to a second conductive structure located beneath the patient'"'"'s scalp.

40. The method of claim 31 wherein implanting an electrode device includes implanting multiple electrode assemblies and wherein the method further comprises coupling the multiple electrode assemblies to a single pulse generator.

41. A method for treating a brain disorder, comprising:

implanting an electrode assembly within a patient'"'"'s skull so that at least one electrical contact of the assembly is positioned at least 0.5 mm from the nearest major blood vessel, sinus, vascular trunk or vascular branch; and

applying an electrical signal to the at least one electrical contact.

42. The method of claim 41 wherein implanting an electrode assembly includes implanting an electrode assembly so that the at least one electrical contact is spaced apart from the nearest vascular structure by a distance of from about 0.5 mm to about 2.0 mm.

43. The method of claim 41 wherein implanting an electrode assembly includes implanting an electrode assembly so that the at least one electrical contact is spaced apart from the nearest vascular structure by a distance of about 1.0 mm

44. The method of claim 41 wherein applying an electrical signal includes stimulating at least a portion of the auditory cortex.

45. The method of claim 41 wherein applying an electrical signal includes stimulating at least a portion of the somatosensory cortex.

46. The method of claim 41 wherein applying an electrical signal includes stimulating at least a portion of Heschl'"'"'s gyri.

47. The method of claim 41 wherein applying an electrical signal includes stimulating at least a portion of at least one of the primary auditory cortex, the secondary auditory cortex, and the secondary somatosensory cortex.

48. A method for treating a brain disorder, comprising:

determining an electrical stimulation site in a patient'"'"'s brain;

determining a location of vasculature located within the patient'"'"'s brain proximate to the electrical stimulation site;

selecting an implantation site for an electrode device to limit the amount of electrical current directed from the electrode device to the vasculature;

implanting the electrode device at the stimulation site; and

applying an electrical signal to at least one electrical contact of the electrode device.

49. The method of claim 48 wherein applying an electrical signal includes stimulating at least a portion of the auditory cortex.

50. The method of claim 48 wherein applying an electrical signal includes stimulating at least a portion of the somatosensory cortex.

51. The method of claim 48 wherein applying an electrical signal includes stimulating at least a portion of Heschl'"'"'s gyri.

52. The method of claim 48 wherein applying an electrical signal includes stimulating at least one of the primary auditory cortex, the secondary auditory cortex, and the secondary somatosensory cortex.

53. The method of claim 48 wherein implanting the electrode device includes implanting the electrode device at one from the group of an epidural and a subdural location.

54. The method of claim 48 wherein applying an electrical signal includes applying a unipolar signal.

55. The method of claim 48 wherein applying an electrical signal includes applying a bipolar signal.

56. The method of claim 48 wherein implanting the electrode device includes positioning a first contact adjacent to and on one side of a vascular structure, and positioning a second contact adjacent to and on an opposite side of the cranial vascular structure.

57. The method of claim 48 wherein implanting the electrode device includes positioning the at least one contact proximate to the Sylvian fissure.

58. The method of claim 48 wherein applying an electrical signal includes alternating between a bipolar and a unipolar electrical signal.

59. The method of claim 48, further comprising varying at least one parameter according to which the electrical signal is applied while the electrode device is implanted beneath the patient'"'"'s skull.

60. The method of claim 48 wherein applying an electrical signal includes transferring the electrical signal from a first conductive structure located external to the patient'"'"'s scalp, via the patient'"'"'s scalp to a second conductive structure located beneath the patient'"'"'s scalp.

61. A method for treating a brain disorder, comprising:

implanting at least one electrode device within a patient'"'"'s skull so that at least one electrical contact of the electrode device is positioned at least proximate to a neuronal cell that is elongated generally along an axis that is generally not perpendicular to the skull proximate to the neuronal cell; and

applying an electrical signal to the at least one electrical contact along electrical field lines that are generally aligned with the axis.

62. The method of claim 61 wherein applying an electrical signal includes applying an electrical signal along electrical field lines that are generally parallel to the skull proximate to the neuronal cell.

63. The method of claim 61 wherein implanting at least one electrode device includes implanting a first electrode device having a first electrical contact and implanting a second electrode device having a second electrical contact spaced apart from the first electrical contact, and wherein applying an electrical signal includes directing an electrical signal from the first electrode to the second electrode, generally parallel to the axis.

64. The method of claim 61 wherein implanting the electrode device includes implanting the electrode device at one from the group of an epidural and a subdural location.

65. The method of claim 61 wherein applying an electrical signal includes applying a unipolar signal.

66. The method of claim 61 wherein applying an electrical signal includes applying a bipolar signal.

67. The method of claim 61 wherein implanting the electrode device includes positioning a first electrical contact adjacent to and on one side of a cranial vascular structure, and positioning a second electrical contact adjacent to and on an opposite side of the cranial vascular structure.

68. The method of claim 61 wherein implanting the electrode device includes positioning the at least one electrical contact proximate to the Sylvian fissure.

69. The method of claim 61 wherein applying an electrical signal includes alternating between a bipolar and a unipolar electrical signal.

70. The method of claim 61, further comprising varying at least one parameter according to which the electrical signal is applied while the electrode device is implanted beneath the patient'"'"'s skull.

71. The method of claim 61 wherein applying an electrical signal includes transferring the electrical signal from a first conductive structure located external to the patient'"'"'s scalp, via the patient'"'"'s scalp to a second conductive structure located beneath the patient'"'"'s scalp.

72. The method of claim 61 wherein implanting an electrode assembly includes implanting multiple electrode assemblies and wherein the method further comprises coupling the multiple electrode assemblies to a single pulse generator.

73. A method for treating tinnitus, comprising:

identifying a target auditory neural population of a patient'"'"'s brain;

implanting an electrode device within the patient'"'"'s skull, with at least one electrical contact of the electrode device at least proximate to the target auditory neural population; and

stimulating the target auditory neural population by applying a unipolar electrical signal to the at least one electrical contact.

74. The method of claim 73 wherein the target neural population projects into the Sylvian fissure of the patient'"'"'s brain, and wherein implanting an electrode device includes implanting an electrode device proximate to the Sylvian fissure so that an axis that is generally normal to the skull and passes through at least one electrical contact of the electrode device is offset from the target auditory neural population.

75. The method of claim 73 wherein stimulating the target neural auditory population includes stimulating a first neural structure and affecting the functioning of a second neural structure that communicates with the first neural structure.

76. The method of claim 73 wherein stimulating the target auditory neural population includes stimulating at least a portion of the auditory cortex.

77. The method of claim 73 wherein stimulating the target auditory neural population includes stimulating at least a portion of the somatosensory cortex.

78. The method of claim 73 wherein stimulating the target auditory neural population includes stimulating at least a portion of Heschl'"'"'s gyri.

79. The method of claim 73 wherein stimulating the target auditory neural population includes stimulating at least a portion of the secondary somatosensory cortex.

80. The method of claim 73 wherein stimulating the target auditory neural population includes stimulating at least a portion of the secondary somatosensory cortex.

81. The method of claim 73 wherein stimulating the target auditory neural population includes stimulating the auditory cortex and the somatosensory cortex, simultaneously or alternately.