Combination therapy for treatment of fibrotic disorders
First Claim
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1. A method of treating a fibrotic disease in an individual, the method comprising administering to an individual suffering from a fibrotic disease a synergistic combination of IFN-γ
- and pirfenidone or a specific pirfenidone analog that is effective in the treatment or prophylaxis of the fibrotic disease in the individual.
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Abstract
The present invention provides methods of treating a fibrotic disorder. The methods generally involve administering an effective amount of IFN-γ and an effective amount of pirfenidone or a pirfenidone analog.
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Citations
11 Claims
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1. A method of treating a fibrotic disease in an individual, the method comprising administering to an individual suffering from a fibrotic disease a synergistic combination of IFN-γ
- and pirfenidone or a specific pirfenidone analog that is effective in the treatment or prophylaxis of the fibrotic disease in the individual.
- View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11)
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2. A method of treating a fibrotic disease in an individual, the method comprising administering to an individual suffering from a fibrotic disease a combination of IFN-γ
- and pirfenidone or a specific pirfenidone analog that is effective in the treatment or prophylaxis of the fibrotic disease in the individual and that reduces the incidence or severity of one or more side effects ordinarily associated with the administration of either drug alone in the treatment of the fibrotic disease.
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3. A method of treating a fibrotic disease in an individual, the method comprising administering to an individual suffering from a fibrotic disease a combined dosage of about 50 mcg to about 200 mcg IFN-γ
- three times weekly and about 400 mg to about 3600 mg pirfenidone or a specific pirfenidone analog daily.
Specification