ß binding molecules
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer'"'"'s disease, Down'"'"'s syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.
-
Citations
44 Claims
-
1-24. -24. (canceled)
-
25. An antibody, or an antigen-binding portion thereof, that binds human Aβ
- , wherein the light chain and heavy chain CDRs are those of antibody 6C3, such that the antibody or antigen-binding portion thereof comprises;
a) a light chain CDR1 comprising the amino acid sequence of SEQ ID NO;
7;
b) a light chain CDR2 comprising the amino acid sequence of SEQ ID NO;
23;
c) a light chain CDR3 comprising the amino acid sequence of SEQ ID NO;
34;
d) a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO;
37;
e) a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO;
41; and
f) a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO;
71. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34)
- , wherein the light chain and heavy chain CDRs are those of antibody 6C3, such that the antibody or antigen-binding portion thereof comprises;
-
35. An antibody, or an antigen-binding portion thereof, that binds human Aβ
- , wherein the light chain and heavy chain CDRs are those of antibody 1A1, such that the antibody or antigen-binding portion thereof comprises;
a) a light chain CDR1 comprising the amino acid sequence of SEQ ID NO;
8;
b) a light chain CDR2 comprising the amino acid sequence of SEQ ID NO;
23;
c) a light chain CDR3 comprising the amino acid sequence of SEQ ID NO;
34;
d) a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO;
38;
e) a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO;
59; and
f) a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO;
71. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44)
- , wherein the light chain and heavy chain CDRs are those of antibody 1A1, such that the antibody or antigen-binding portion thereof comprises;
Specification