Topical Delivery System for Cosmetic and Pharmaceutical Agents

• US 20060110415A1
• Filed: 11/22/2004
• Published: 05/25/2006
• Est. Priority Date: 11/22/2004
• Status: Abandoned Application

• Current Assignee: Bioderm Research
• Original Assignee: Bioderm Research
• Inventors: Gupta, Shyam K.
• Application Number:
  US10/904,665
• Publication Number:
  US 20060110415A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 8/0212 Face masks
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

This invention relates to topical compositions containing esters of hydroxy acids and their application in the deep-penetration delivery of beneficial cosmetic and pharmaceutical agents.

Claims

1. Cosmetic and pharmaceutical compositions comprising;

(i) at least one skin penetration enhancing agent selected from an ester of a hydroxy acid, and (ii) at least one cosmetic or pharmaceutical agent.

2. A composition according to claim 1, wherein the said composition comprises from about 1% to about 99% by weight of a skin penetration enhancing agent, and from about 0.0001% to about 95% of a cosmetic or pharmaceutical agent.

3. A composition according to claim 1, wherein an ester of a hydroxy acid is selected from alkyl and aryl esters of Glycolic Acid, alkyl and aryl esters of Malic Acid, alkyl and aryl esters of Lactic Acid, alkyl and aryl esters of Mandelic Acid, alkyl and aryl esters of Ascorbic Acid, alkyl and aryl esters of Phytic Acid, alkyl and aryl esters of Salicylic Acid, alkyl and aryl esters of Aleuritic Acid, alkyl and aryl esters of Tartaric Acid, alkyl and aryl esters of Citric Acid, alkyl and aryl esters of Hydroxytetronic Acid, alkyl and aryl esters of hydroxycitric acid, alkyl and aryl esters of Glucuronic Acid, alkyl and aryl esters of Hyaluronic Acid, alkyl and aryl esters of Mucic Acid, alkyl and aryl esters of Galacturonic Acid, alkyl and aryl esters of Gluconic Acid, alkyl and aryl esters of Saccharic Acid, alkyl and aryl esters of Glucoheptonic Acid, alkyl and aryl esters of alpha-Hydroxybutyric Acid, alkyl and aryl esters of Hydroxystearic acid, Trihydroxystearin esters, alkyl and aryl esters of Tartronic Acid, alkyl and aryl esters of alpha-Hydroxyisobutyric Acid, alkyl and aryl esters of Isocitric Acid, alkyl and aryl esters of alpha-Hydroxyisocaproic Acid, alkyl and aryl esters of Dihydroxymaleic Acid, alkyl and aryl esters of alpha-Hydroxyisovaleric Acid, alkyl and aryl esters of Dihydroxytartaric Acid, alkyl and aryl esters of beta-Hydroxybutyric Acid, alkyl and aryl esters of Dihydroxyfumaric Acid, alkyl and aryl esters of beta-Phenyllactic Acid, alkyl and aryl esters of Atrolactic Acid, alkyl and aryl esters of Galactonic Acid, alkyl and aryl esters of Pantoic Acid, alkyl and aryl esters of Glyceric Acid, and combinations thereof.

4. A composition according to claim 1, wherein the cosmetic or pharmaceutical agent is selected from the group consisting of an antifungal agent, an antibacterial agent, an antiviral agent, an anti-acne agent, an antiaging agent, an anti-pruritic agent, a UV absorbing agent, a sunscreen agent, a skin pigment modulating agent, a skin lightening agent, a skin darkening agent, a hair growth enhancing agent, a hair growth inhibiting agent, an antidandruff agent, an anti-seborrheic agent, an anti-psoriasis agent, a hair removal agent, an exfoliating agent, a wound healing agent, an anti-inflammatory agent, a blood microcirculation improvement agent, a sebum modulating agent, a hormone, an immune modulating agent, a botanical extract, a moisturizing agent, an emollient, an astringent, an antiperspirant, a vitamin, a retinoid, a cleansing agent, a sensory agent, a color change agent, an antibiotic, an anti-irritant, an anesthetic, an analgesic, a steroid, a tissue healing agent, a tissue regenerating agent, a collagen or elastin boosting agent, a skin protectant agent, an agent to promote excess fat reduction or cellulite control or body toning benefits, an amino acid, a peptide, a mineral, a hydroxy acid, an anti-emetic agent, an anti-anginal agent, a bronchodilator agent, osteoporosis treatment agent, an anti-depressant agent, an anti-migraine agent, smoking cessation agent, anti-diarrheal agent, anti-ulcer agent, mood disorder agent, anti-obesity agents, erectile dysfunction control agents, anti-Parkinson agents, MAO inhibitors, sleep disorder agents, anti-diabetic agents, or combinations thereof.

5. A composition according to claim 1, wherein the skin penetration enhancing agent is selected from methyl lactate, ethyl lactate, propyl lactate, isopropyl lactate, butyl lactate, isobutyl lactate, t-butyl lactate, pentyl lactate, neopentyl lactate, isopentyl lactate, hexyl lactate, ethylhexyl lactate, glycerol lactate, benzyl lactate, triethyl citrate, trimethyl citrate, tributyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, trihexyl citrate, butyl trihexyl citrate, stearyl citrate, diethyl tartrate, dimethyl tartrate, ethyl mandelate, ethyl salicylate, methyl salicylate, ethyl glycolate, and combinations thereof.

6. A composition according to claim 1, wherein a rheology-modifying agent is also included.

7. A composition according to claim 1, wherein a carrier base or a delivery system is included.

8. A composition according to claim 1, wherein heat-release agent is included.

9. A composition according to claim 3, wherein an ester of a hydroxy acid is further selected from the group consisting of:

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of glycolic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of lactic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of methyl lactic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxybutanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxypentanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxyhexanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxyheptanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxyoctanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxynonanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxydecanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxyundecanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxydodecanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxytetradecanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxyhexadecanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxyoctadecanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxyeicosanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxytetraeicosanoic acid; and

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-hydroxytetraeicosenoic acid, and combinations thereof.

10. A method according to claim 3, wherein said alpha hydroxyacid ester is an aryl 2-hydroxycarboxylic acid ester further selected from the group consisting of:

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-phenyl 2-hydroxyethanoic acid esters;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2,2-diphenyl 2-hydroxyethanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 3-phenyl 2-hydroxypropanoic acid; and

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl and dodecyl esters of 2-phenyl 2-methyl 2-hydroxyethanoic acid, and combinations thereof.

11. A method according to claim 3, wherein said alpha hydroxyacid ester is an polyhydroxyacid ester selected from the group consisting of:

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of 2,3-dihydroxypropanoic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of 2,3,4-trihydroxybutanoic acid and its isomers including erythronic acid and threonic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of 2,3,4,5-tetrahydroxypentanoic acid and its isomers including ribonic acid, arabinoic acid, xylonic acid and lyxonic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of 2,3,4,5,6-pentahydroxyhexanoic acid and its isomers including allonic acid, altronic acid, gluconic acid, mannoic acid, gulonic acid, idonic acid, galactonic acid, and talonic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of 2,3,4,5,6,7-hexahydroxyheptanoic acid and its isomers including glucoheptonic acid and galactoheptonic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of glyceruronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of erythruronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of threuronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of riburonic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of arabinuronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of xyluronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of lyxuronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of alluronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of altruronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of glucuronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of mannuronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of guluronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of iduronic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of galacturonic acid; and

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of taluronic acid, and combinations thereof.

12. A method according to claim 3, wherein said alpha hydroxyacid ester is a hydroxypolyacid ester further selected from the group consisting of:

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl and benzyl esters of 2-hydroxypropane-1,3-dioic acid;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl, benzyl, dimethyl, diethyl, dipropyl, diisopropyl, dibutyl, dipentyl, dioctyl, didecyl, didodecyl, diphenyl and dibenzyl esters of 2-hydroxybutane-1,4-dioic acid esters;

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl, benzyl, dimethyl, diethyl, dipropyl, diisopropyl, dibutyl, dipentyl, dioctyl, didecyl, didodecyl, diphenyl and dibenzyl esters of 2,3-dihydroxybutane-1,4-dioic acid; and

the methyl, ethyl, propyl, isopropyl, butyl, pentyl, octyl, decyl, dodecyl, phenyl, benzyl, dimethyl, diethyl, dipropyl, diisopropyl, dibutyl, dipentyl, dioctyl, didecyl, didodecyl, diphenyl, dibenzyl, trimethyl, triethyl, tripropyl, triisopropyl, tributyl, tripentyl, trioctyl, tridecyl, tridodecyl, triphenyl and tribenzyl esters of 3-hydroxy-3-carboxypentane-1,5-dioic acid, and combinations thereof.

13. A composition according to claim 4, wherein the agent to promote excess fat reduction or cellulite control or body toning benefits is selected from Forskohlin extract (from Coleus forskohlii plant), Hydroxycitric acid, (from Garcinia cambogia, and plants of Garcinia family), L-Carnitine, Creatine, Human growth hormone (HGH), Chromium picolinate, Kola seed extract, Caffeine, Niacinamide, Psyllium husk, Chitosan, Lipoprotein complexes, Polyphenols, Gymnemic acid, Pyruvic acid and Pyruvate salts, salts of Hydroxycitric acid, Phaseolamine (from Phaseolus vulgaris extract), DHEA, Chitosan, Theophylline, Theobromine (or salts thereof such as Aminophylline), Roselle tea extract, Arabinose, Inosine, Adenosine, Fructose-1,6-diphosphate, Adenosine triphosphate (ATP), Adenosine diphosphate (ADP), Indomethacin, Baicalein, Extract of the plant of genus Tephrosia, Natriuretic peptide, Laminaria extract, Extract from berries of Panax genus plant, Gymnema sylvestre extract, 9-cis, 11-trans Conjugated linoleic acid and 10-trans, 12-cis conjugated linoleic acid isomers (conjugated linoleic acid, CLA), Synephrine, Hordenine, Octopamine, Tyramine, N-Methyltyramine, Azaftig, Extract of Climbing ivy (Hedera helix), Extract of Arnica (Arnica montana), Extract of Rosemary (Rosmarinus officinalis), Extract of Marigold (Calendula officinalis), Extract of Sage (Salvia officinalis), Extract of Ginseng (Panax ginseng), Extract of St. Johns-wart (Hypericum perforatum), Extract of Ruscus (Ruscus aculeatus), Extract of meadowsweet (Filipendula ulmaria), Extract of Orthosiphon (Ortosifon stamincus), and combinations thereof.

14. A composition according to claim 4, wherein the collagen and elastin boosting agent is selected from Ascorbic acid, Ascorbic acid derivatives, Glucosamine ascorbate, Arginine ascorbate, Lysine ascorbate, Glutathione ascorbate, Nicotinamide ascorbate, Niacin ascorbate, Allantoin ascorbate, Creatine ascorbate, Creatinine ascorbate, Chondroitin ascorbate, Chitosan ascorbate, DNA Ascorbate, Carnosine ascorbate, Vitamin E, various Vitamin E derivatives, Tocotrienol, Rutin, Quercetin, Hesperedin (Citrus sinensis), Diosmin (Citrus sinensis), Mangiferin (Mangifera indica), Mangostin (Garcinia mangostana), Cyanidin (Vaccinium myrtillus), Astaxanthin (Haematococcus algae), Lutein (Tagetes patula), Lycopene (Lycopersicum esculentum), Resveratrol (Polygonum cuspidatum), Tetrahydrocurcumin (Curcuma longa), Rosmarinic acid (Rosmarinus officinalis), Hypericin (Hypericum perforatum), Ellagic acid (Punica granatum), Chlorogenic acid (Vaccinium vulgaris), Oleuropein (Olea europaea), α

-Lipoic acid, Niacinamide lipoate, Glutathione, Andrographolide (Andrographis paniculata), Carnosine, Niacinamide, Potentilla erecta extract, Polyphenols, Grapeseed extract, Pycnogenol (Pine Bark extract), and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

A composition according to claim 4, wherein the hydroxy acid is selected from the group consisting of salicylic acid, lactic acid, glycolic acid, malic acid, mandelic acid, ascorbic acid, ascorbyl phosphoric acid, hydroxycitric acid, hydroxytetronic acid, citric acid, aleuritic acid, ellagic acid, rosmarinic acid, chlorogenic acid, polysulfonic acid, phytic acid, and hyaluronic acid (HYA). The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

15. A composition according to claim 4, wherein the skin whitening agent is selected from hydroquinone, arbutin, hydroquinone derivatives, Paper Mulberry extract (Broussonetia kazinoke), Mitracarpe extract (Mitracarpus scaber), Bearberry extract (Arctostaphylos uva ursi), Yellow Dock extract (Rumex crispus and Rumex occidentalis), Glutathione, Leucocyte extract, Aspergillus orizae extract (Aspergillus orizae), Licorice Root extract (Glycyrrhiza glabra), Rosmarinic acid (Rosmarinus officinalis), Tetrahydrocurcumin, Green Tea extract (Camellia sinensis), Yohimbe extract (Pausinystalia yohimbe), Ecklonia cava extract, niacinamide, Hydroxytetronic acid, Spondias mombin extract, Maprounea guianensis extract, Walteria indica extract, Gouania blanchetiana extract, Cordia schomburgkii extract, Randia armata extract, Hibiscus furcellatus extract, and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

16. A composition according to claim 4, wherein additional skin whitening agent is further selected from 2-hydroxyacetophenone, 3-hydroxyacetophenone, 4-hydroxyacetophenone, 2,3-dihydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,5-dihydroxyacetophenone, 2,6-dihydroxyacetophenone, 3,4-dihydroxyacetophenone, 3,5-dihydroxyacetophenone, 2,4,6-trihydroxyacetophenone, 2,3,4-trihydroxyacetophenone, 2,3,5-trihydroxyacetophenone, 2,3,6-trihydroxyacetophenone, 2,4,5-trihydroxyacetophenone, 3,4,5-trihydroxyacetophenone, Resacetophenone, 2-Acetyl resorcinol, 4-Acetyl resorcinol, 3,4-Dihydroxyacetophenone, acetyl quinol, Quinacetophenone, 1-(3-Hydroxy-4-methoxy-5-methylphenyl) ethanone, 1-(3-hydroxy-4-methoxyphenyl) ethanone, Paeonol, 5′

-Bromo-2′

-hydroxyacetophenone, 5′

-Chloro-2′

-hydroxyacetophenone, 3′

,5′

-Dichloro-2′

-hydroxyacetophenone, 3′

,5′

-Dibromo-4′

-hydroxyacetophenone, 5-Chloro-3-bromo-2-hydroxyacetophenone, and combinations thereof.

17. A composition according to claim 4, wherein the antioxidant is selected from Ascorbic acid, Ascorbic acid derivatives, Vitamin E, Vitamin E derivatives, Tocotrienol, Rutin, Quercetin, Hesperedin (Citrus sinensis), Diosmin (Citrus sinensis), Mangiferin (Mangifera indica), Mangostin (Garcinia mangostana), Cyanidin (Vaccinium myrtillus), Astaxanthin (Haematococcus algae), Lutein (Tagetes patula), Lycopene (Lycopersicum esculentum), Resveratrol (Polygonum cuspidatum), Tetrahydrocurcumin (Curcuma longa), Rosmarinic acid (Rosmarinus officinalis), Hypericin (Hypericum perforatum), Ellagic acid (Punica granatum), Chlorogenic acid (Vaccinium vulgaris), Oleuropein (Olea europaea), alpha-Lipoic acid, Glutathione, Andrographolide, Grapeseed extract, Green Tea Extract, Polyphenols, Pycnogenol (Pine Bark extract), White Tea extract, Black Tea extract, (Andrographis paniculata), Carnosine, Niacinamide, Emblica extract, and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

18. A composition according to claim 4, wherein the UVA/UVB sunscreen agent is selected from Titanium dioxide, Zinc oxide, Galanga extract (Kaempferia galanga), Benzophenone-3, Benzophenone-4, Ethylhexyl Methoxycinnamate, Homosalate, Ethylhexyl salicylate, Octocrylene, Menthyl anthranilate, Avobenzone, Lawsone, Sulisobenzone, Trolamine salicylate, Lawsone, Glyceryl aminobenzoate, Cinoxate, and PABA. and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

19. A Composition According to claim 4, wherein the blood microcirculation improvement composition is selected from Horse Chestnut Extract (Aesculus hippocastanum extract)), Esculin, Escin, Yohimbine, Capsicum Oleoresin, Capsaicin, Niacin, Niacin Esters, Methyl Nicotinate, Benzyl Nicotinate, Ruscogenins (Butchers Broom extract;

Ruscus aculeatus extract), Diosgenin (Trigonella foenumgraecum, Fenugreek), Emblica extract (Phyllanthus emblica extract), Asiaticoside (Centella asiatica extract), Boswellia Extract (Boswellia serrata), Sericoside, Visnadine, Thiocolchicoside, Grapeseed Extract, Ginger Root Extract (Zingiber Officianalis), Piperine, Vitamin K, Melilot (Melilotus officinalis extract), Glycyrrhetinic acid, Ursolic acid, Sericoside (Terminalia sericea extract), Darutoside (Siegesbeckia orientalis extract), Amni visnaga extract, extract of Red Vine (Vitis-Vinifera) leaves, apigenin, phytosan, luteolin, and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

20. A composition according to claim 4, wherein the antimicrobial agent is selected from Berberine, Triclosan, Triclocarban, various Tritons (quaternary ammonium compounds), Benzyl Alcohol, Dehydroacetic Acid, Phenoxyethanol, and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

21. A composition according to claim 4, wherein the vitamin is selected from Vitamin A, Retinol, Retinoic acid, Tretinoin, members of Vitamins B group, Vitamin C, Vitamin D, Vitamin E, Vitamin K, Carotenes, Biotin, Folic Acid, and their derivatives, and combinations thereof. The quantities of such ingredients can be safe and effective amounts as needed, and not limited to any specific limits.

22. A composition according to claim 4, wherein anti-inflammatory agent is selected from 2-hydroxyacetophenone, 3-hydroxyacetophenone, 4-hydroxyacetophenone, 2,3-dihydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,5-dihydroxyacetophenone, 2,6-dihydroxyacetophenone, 3,4-dihydroxyacetophenone, 3,5-dihydroxyacetophenone, 2,4,6-trihydroxyacetophenone, 2,3,4-trihydroxyacetophenone, 2,3,5-trihydroxyacetophenone, 2,3,6-trihydroxyacetophenone, 2,4,5-trihydroxyacetophenone, 3,4,5-trihydroxyacetophenone, Resacetophenone, 2-Acetyl resorcinol, 4-Acetyl resorcinol, 3,4-Dihydroxyacetophenone, acetyl quinol, Quinacetophenone, 1-(3-Hydroxy-4-methoxy-5-methylphenyl) ethanone, 1-(3-hydroxy-4-methoxyphenyl) ethanone, Paeonol, 5′

-Bromo-2′

-hydroxyacetophenone, 5′

-Chloro-2′

-hydroxyacetophenone, 3′

,5′

-Dichloro-2′

-hydroxyacetophenone, 3′

,5′

-Dibromo-4′

-hydroxyacetophenone, 5-Chloro-3-bromo-2-hydroxyacetophenone, and combinations thereof.

23. A composition according to claim 4, wherein the hormone can be selected from progesterone, androsterone, dehydroepiandrosterone (DHEA), Pregnenolone, androstenedione, melatonin, testosterone, and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

24. A composition according to claim 4, wherein the skin protectant drug is selected from Allantoin, petrolatum, glycerin, dimethicone, urea, calamine, cocoa butter, kaolin, zinc acetate, zinc carbonate, and combinations thereof. The quantities of such compositions can be safe and effective amounts as needed, and not limited to any specific limits.

25. A composition according to claim 4, wherein skin beneficial ingredient is selected from various trace metal delivery systems, which includes copper, zinc, and manganese in their both free and chelated forms.

26. A composition according to claim 4, wherein moisturizing agents are selected from polyethylene glycol, polypropylene glycol, polybutylene glycol, mixed grafted polyethylene and polypropylene glycols, butylene glycol, mixed grafted polyethylene and polybutylene glycols, propylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, octanediol, methylpropanediol, methoxypolyethylene glycols, polyglycol copolymers, methylsulfonylmethane (MSM), polyvinyl pyrrolidone, N-methylpyrrolidone, pyrrolidone, and combinations thereof.

27. A composition according to claim 6, wherein the rheology modifying agent is selected from Hydroxypropyl Guar, Guar Hydroxypropyltrimonium chloride, Hydroxypropyl Starch, Starch Hydroxypropyltrimonium chloride, Hydroxypropyl Inulin, Inulin Hydroxypropyltrimonium chloride, or combinations thereof.

28. A composition according to claim 6, wherein the rheology-modifying agent is Hydroxypropyl Guar.

29. A composition according to claim 6, wherein the rheology-modifying agent is an N-acyl glutamic acid diamide.

30. A composition according to claim 6, wherein the rheology-modifying agent is Ethylenediamine/Hydrogenated Dimer Dilinoleate Copolymer Bis-Di-C14-18 Alkyl Amine (Polyamide-3).

31. A composition according to claim 6, wherein the rheology-modifying agent is selected from Monostearyl Citrate, Distearyl Citrate, Tristearyl citrate, and stearyl citrate.

32. A composition according to claim 6, wherein the rheology-modifying agent is Trihydroxystearin.

33. A composition according to claim 6, wherein the rheology-modifying agent is further selected from the group consisting of aminoalkyl methacrylate copolymer RS, aminoalkyl methacrylate copolymer E, methacrylate copolymer L, methacrylate copolymer S, methacrylic acid/ethyl methacrylate copolymer, methacrylic acid/methyl methacrylate copolymer, methacrylic acid/ethyl acrylate copolymer, ethylcellulose, polyvinyl acetal diethylaminoacetate, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, carboxymethyl ethylcellulose, cellulose acetophthalate, rosin, sandarac, celluloid, shellac, and zein.

34. A composition according to claim 7, wherein a cosmetically or pharmaceutically acceptable delivery system or a carrier base can be selected in the form of a lotion, cream, gel, spray, thin liquid, body splash, mask, serum, solid cosmetic stick, lip balm, shampoo, liquid soap, bar soap, bath oil, cologne, hair conditioner, salve, collodion, impregnated patch, impregnated strip, skin surface implant, and any other such cosmetically or pharmaceutically acceptable topical delivery forms.

35. The compositions according to claim 7, wherein the cosmetically or pharmaceutically acceptable delivery system can be traditional water and oil emulsions, suspensions, colloids, microemulsions, clear solutions, suspensions of nanoparticles, emulsions of nanoparticles, or anhydrous compositions.

36. A composition according to claim 7, wherein cosmetically or pharmaceutically acceptable delivery system or carrier base can optionally include additional skin beneficial ingredients selected from skin cleansers, surfactants (cationic, anionic, non-ionic, amphoteric, and zwitterionic), skin and hair conditioning agents, vitamins, hormones, minerals, plant extracts, anti-inflammatory agents, concentrates of plant extracts, emollients, moisturizers, skin protectants, humectants, silicones, skin soothing ingredients, analgesics, skin penetration enhancers, solubilizers, moisturizers, emollients, anesthetics, colorants, perfumes, preservatives, seeds, broken seed nut shells, silica, clays, beads, luffa particles, polyethylene balls, mica, pH adjusters, processing aids, and combinations thereof. The quantities of such ingredients can be safe and effective amounts as needed, and not limited to any specific limits.

37. A composition according to claim 8, wherein heat-release agents are selected from anhydrous zeolites, anhydrous silicates, anhydrous silica gels, anhydrous calcium sulfate, anhydrous sodium sulfate, glycerin, diglycerol, polyglycerol, polyethylene glycols, and combinations thereof.