Methods and compositions for therapeutic treatment
First Claim
1. A composition comprising a therapeutic agent and an blood-brain barrier (BBB) transport protein modulator, wherein the therapeutic agent is present in an amount sufficient to exert a therapeutic effect and the BBB transport protein modulator is present in an amount sufficient to decrease a central nervous system (CNS) effect of the therapeutic agent by an average of at least about 10%, compared to the CNS effect without the BBB transport protein modulator, when the composition is administered to an animal.
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Abstract
Methods and compositions are described for the modulation of central nervous system and/or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compounds from physiological compartments, including central nervous system and fetal compartments.
105 Citations
44 Claims
- 1. A composition comprising a therapeutic agent and an blood-brain barrier (BBB) transport protein modulator, wherein the therapeutic agent is present in an amount sufficient to exert a therapeutic effect and the BBB transport protein modulator is present in an amount sufficient to decrease a central nervous system (CNS) effect of the therapeutic agent by an average of at least about 10%, compared to the CNS effect without the BBB transport protein modulator, when the composition is administered to an animal.
- 19. A method of treating a condition comprising administering to an animal suffering from the condition an effective amount of a therapeutic agent and an amount of an BBB transport protein activator sufficient to reduce or eliminate a CNS effect of the therapeutic agent.
- 41. A method for reversing a central nervous system effect of an agent in a human comprising administering to the human an amount of a BBB transport protein modulator sufficient to partially or completely reverse a central nervous system effect of the agent, wherein said human has received an amount of said agent sufficient to produce a central nervous system effect.
Specification