Compositions for treating or preventing obesity and insulin resistance disorders
First Claim
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1. A method for treating or preventing insulin resistance disorder in a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of an agent that increases the activity and/or protein level of a sirtuin in a cell.
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Abstract
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
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Citations
29 Claims
- 1. A method for treating or preventing insulin resistance disorder in a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of an agent that increases the activity and/or protein level of a sirtuin in a cell.
- 7. A method for reducing the weight of a subject, or preventing weight gain in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an agent that increases the activity or protein level of a sirtuin in a cell.
- 13. A method for promoting weight gain in a subject in need thereof, comprising administering to a subject in need thereof a therapeutically effective amount of an agent that reduces the activity or protein level of a sirtuin in a cell.
- 22. A method for preventing fat accumulation in a cell with lipogenic capacity, comprising contacting the cell with an agent that increases the activity or protein level of a sirtuin.
- 23. A method for enhancing fat accumulation in, or adipogenesis of, a cell, comprising contacting a cell with an agent that decreases the activity or protein level of a sirtuin.
- 26. A method for preventing the differentiation of a pre-adipocyte, comprising contacting the pre-adipocyte with an agent that increases the activity or protein level of a sirtuin in a cell, such that the differentiation of the pre-adipocyte is inhibited.
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28. A method for identifying an agent that modulates weight or weight gain, comprising:
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(i) identifying an agent that modulates a sirtuin; and
(ii) determining the effect of the agent on weight gain, wherein the presence of an effect of the agent on weight or weight gain indicates that the agent modulates weight or weight gain.
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29. A method for identifying an agent for treating or preventing obesity, insulin resistance, metabolic syndrome or diabetes in a subject, comprising:
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(i) identifying an agent that activates a sirtuin; and
(ii) determining the effect of the agent on obesity, insulin resistance, metabolic syndrome or diabetes, wherein a decrease in the presence, degree or occurrence of obesity, insulin resistance, metabolic syndrome or diabetes indicates that the agent is an agent for treating or preventing these conditions.
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Specification