Apparatus and method for monitoring deep tissue temperature using broadband diffuse optical spectroscopy
First Claim
1. A method for noninvasively determining tissue temperature comprising:
- measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy; and
generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore.
2 Assignments
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Accused Products
Abstract
A method for noninvasively determining deep tissue temperature comprises measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy and generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore. A bound water correction is made to the spectral shift. A frequency domain measurement at multiple wavelengths is made to determine the absolute absorption and scattering values between 600 and 1050 nm. The measurement of an absolute absorption comprises measuring an absolute absorption coefficient of selected tissue and further comprising deducing concentrations of tissue composition including lipids, deducing information related to heterogeneity and integrity of tissue matrix, and deducing temperature heterogeneity related to vulnerable plaque in vascular tissue. The measurement comprises making a measurement in the range of 600-1100 nm to interrogate a vessel wall in the presence of blood.
28 Citations
29 Claims
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1. A method for noninvasively determining tissue temperature comprising:
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measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy; and
generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for noninvasively determining an unknown tissue chromophore comprising:
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measuring data relating to spectral shifts of the unknown chromophore absorption in tissue using broadband diffuse optical spectroscopy;
generating a temperature reading corresponding to a spectral shift of an absorption peak of the unknown chromophore; and
matching a spectral shift of an absorption peak of a known chromophore selected from a library to the spectral shift of an absorption peak of the unknown chromophore to obtain a best fit among a plurality of known chromophore candidates to identify the unknown chromophore with the known chromophore.
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15. A method for noninvasively detecting vulnerable plaque in vascular tissue comprising:
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measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy corresponding to at least one chromophore correlated with vulnerable plaque in vascular tissue; and
generating at least one temperature reading corresponding to the spectral shift of an absorption peak of the at least one chromophore to identify temperature heterogeneity in the vascular tissue and presence of vulnerable plaque.
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16. An apparatus for noninvasively determining deep tissue temperature comprising:
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means for measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy; and
means for generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. An apparatus for noninvasively determining an unknown tissue chromophore comprising:
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means for measuring data relating to spectral shifts of the unknown chromophore absorption in tissue using broadband diffuse optical spectroscopy;
means for generating a temperature reading corresponding to a spectral shift of an absorption peak of the unknown chromophore; and
means for matching a spectral shift of an absorption peak of a known chromophore selected from a library to the spectral shift of an absorption peak of the unknown chromophore to obtain a best fit among a plurality of known chromophore candidates to identify the unknown chromophore with the known chromophore.
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29. An apparatus for noninvasively detecting vulnerable plaque in vascular tissue comprising:
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means for measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy corresponding to at least one chromophore correlated with vulnerable plaque in vascular tissue; and
means for generating at least one temperature reading corresponding to the spectral shift of an absorption peak of the at least one chromophore to identify temperature heterogeneity in the vascular tissue and presence of vulnerable plaque.
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Specification