CONTROLLED RELEASE PREPARATION
9 Assignments
0 Petitions
Accused Products
Abstract
Controlled release preparations and capsules are provided. Also provided are emulsions and suspensions, including compositions and methods of manufacturing controlled release capsules, where the fill contains a suspension and/or an emulsion.
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Citations
47 Claims
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1-11. -11. (canceled)
- 12. A controlled release soft capsule having a shell and a matrix fill comprising an active ingredient or drug, wherein the matrix fill comprises two phases in the form of an emulsion.
- 32. A controlled release hard shell capsule comprising a shell and a matrix fill, wherein the matrix fill comprises an active ingredient or drug incorporated as solid particles in lipid or lipophilic materials.
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43. A method of manufacturing a matrix fill for a controlled release soft capsule, the method comprising
a) applying heat to matrix components during mixing or prior to mixing at about the melting point of the matrix fill composition; - and
b) mixing the active ingredient or drug with the lipid or lipophilic matrix ingredients using mechanical or ultrasonic forces to form the matrix fill. - View Dependent Claims (44, 45, 46)
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47. A method of manufacturing a controlled release soft capsule, wherein the matrix fill includes two phases in the form of an emulsion, the method comprising
a) dispersing the active ingredient or drug in an internal phase to form a clear solution or suspension using propeller or homogenizer mixers; -
b) adding the internal phase to a molten external phase containing at least one surfactant in an amount from about 0.1% to about 5% by weight to form a resulting mixture;
c) forming an emulsion from the resulting mixture by subjecting the mixture to mechanical forces generated by a propeller mixer, a homogenizer, or a microfluidizer;
d) cooling the emulsion to from about 20°
C. to about 35°
C.; and
e) encapsulating the emulsion using a rotary die encapsulation machine to form the controlled release capsule.
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Specification