Extraction device, analyzer, extraction method, and analysis method

• US 20060116563A1
• Filed: 11/16/2005
• Published: 06/01/2006
• Est. Priority Date: 11/16/2004
• Status: Active Grant

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Maekawa, Yasunori, Okada, Seiki, Asano, Kaoru
• Granted Patent: US 8,046,043 B2
• Time in Patent Office: Days
• US Class Current: 600/319
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An extraction device for extracting an analyte from living tissue is disclosed that comprises a power source; a first electrode and second electrode connected to the power source; and a holding unit for holding a collecting medium for collecting analyte extracted from living tissue, wherein the collecting medium is in contact with both the first electrode and second electrode continuously. An analyzer comprising the extraction device, method for extracting an analyte, and method for extracting and analyzing an analyte are also described.

Claims

1. An extraction device for extracting an analyte from living tissue comprising:

a power source;

a first electrode and second electrode connected to the power source; and

a holding unit for holding a collecting medium for collecting analyte extracted from living tissue, wherein the collecting medium is in contact with both the first electrode and second electrode continuously.

2. The extraction device of claim 1, wherein the collection medium is a nonconductive material.

3. The extraction device of claim 1, wherein the collection medium is a nonconductive material that allows the migration of ions extracted from living tissue.

4. The extraction device of claim 1, wherein the collection medium is a nonconductive fluid or nonconductive gel.

5. The extraction device of claim 2, wherein the collection medium is purified water.

6. The extraction device of claim 1, wherein the collection medium is a nonconductive fluid, and the extraction device further comprises an absorbing member for absorbing and holding the fluid.

7. The extraction device of claim 6, wherein the absorbing member is paper or mesh sheet.

8. The extraction device of claim 1, wherein at least part of the first electrode and second electrode is formed of material having a specific surface area of 100 m2/g or higher but less than 5000 m2/g.

9. The extraction device of claim 1, wherein the first electrode comprises a positive electrode, the second electrode comprises a negative electrode, and the holding unit holds the positive electrode, negative electrode, and the collecting medium.

10. The extraction device of claim 9, wherein the positive electrode and the negative electrode are arranged in the holding unit so as to be mutually opposed with a predetermined spacing.

11. The extraction device of claim 9, wherein the positive electrode and the negative electrode are arranged in the holding unit so as to not touch the skin when the collecting medium is touching the skin.

12. The extraction device of claim 1, wherein at least one among the first electrode and second electrode comprises a member formed of activated carbon.

13. An analyzer for analyzing an analyte extracted from living tissue comprising:

the extraction device of claim 1;

a detecting unit for detecting analyte collected in the collection medium of the extraction device; and

a control unit for analyzing the analyte extracted in the collection medium based on information obtained from the detecting unit.

14. The analyzer of claim 13 further comprising:

a device body comprising the power source of the extraction device, and the control unit; and

an extraction cartridge that is removably installed in the device body;

wherein the extraction cartridge comprises the first electrode and second electrode of the extraction device, and the holding unit of the analyte extraction device.

15. The analyzer of claim 14, wherein the detecting unit comprises:

a light source;

an analyte sensor being in contact with the collection medium when the extraction cartridge is connected to the device body, and being irradiated with light from the light source; and

an optical sensor for detecting the irradiating light from the light source through the analyte sensor,

wherein the light source and optical sensor are provided in the device body, and the analyte sensor is provided in the extraction cartridge.

16. The analyzer of claim 13, wherein the analyte includes glucose, and the control unit obtains a blood sugar level by analyzing glucose extracted to the collection medium.

17. The analyzer of claim 13 further comprising:

a current value acquiring unit for acquiring the value of the current flowing to the first electrode of the extraction device from the power source of the extraction device,

wherein the control unit obtains the concentration of a component contained in the interstitial fluid in the body of a subject based on the current value acquired by the current value acquiring unit and information obtained by the detecting unit.

18. A method for extracting an analyte from living tissue, comprising the steps of:

bringing a collection medium for collecting analyte extracted from living tissue into contact with the skin, wherein the collection medium is in contact with both a first electrode and a second electrode continuously; and

extracting analyte from the living tissue to the collection medium by applying a voltage between the first electrode and second electrode.

19. A method for analyzing an analyte, comprising the steps of:

extracting an analyte from living tissue to a collection medium for collecting analyte by using the method of claim 18;

and

analyzing the analyte extracted to the collection medium.

20. A device for extracting an analyte from living tissue comprising:

an electric field inducing means for providing an electric field in living tissue through a nonconductive material; and

a collection medium for collecting an analyte extracted from living tissue in the presence of an electric field induced by the electric field inducing means.