Iontophoresis device

• US 20060116628A1
• Filed: 06/30/2005
• Published: 06/01/2006
• Est. Priority Date: 11/30/2004
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcutaneous Technologies, Inc.
• Inventors: Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Application Number:
  US11/172,058
• Publication Number:
  US 20060116628A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An iontophoresis device is capable of suppressing the change in a composition of a drug solution and/or an electrolyte solution of a working electrode structure, thereby allowing the working electrode structure to be retained in a stable state for a long period of time. The iontophoresis device includes: an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity is dissolved; and a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved. A first ion-exchange membrane for selectively passing the ions of the second polarity and a porous separation membrane for blocking passage of molecules and ions each having a molecular weight exceeding a threshold are placed between the electrolyte solution holding part and the drug solution holding part.

Claims

1. An iontophoresis device for administering drug ions to a living body, comprising:

an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved; and

a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part,

wherein a first ion-exchange membrane for selectively passing the ions of the second polarity and a semi-permeable separation membrane for blocking passage of molecules and ions each having a molecular weight greater than a threshold molecular weight are placed between the electrolyte solution holding part and the drug solution holding part.

2. The iontophoresis device according to claim 1 wherein the porous separation membrane blocks passage of the second electrolytic ions.

3. The iontophoresis device according to claim 1 wherein the porous separation membrane blocks passage of one of the electrolyte molecules and the first electrolytic ions.

4. The iontophoresis device according to claim 1 wherein the porous separation membrane blocks passage of one of the drug molecules and the drug ions.

5. The iontophoresis device according to claim 1 wherein the electrolyte solution holding part is sealed in the porous separation membrane formed in a bag shape.

6. The iontophoresis device according to claim 1 wherein the drug solution holding part is sealed in the porous separation membrane formed in a bag shape.

7. An iontophoresis device for administering drug ions to a living body, comprising:

an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved;

a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part; and

a first ion-exchange membrane for selectively passing ions of the second polarity, the first ion-exchange membrane being placed between the electrolyte solution holding part and the drug solution holding part, wherein the first ion-exchange membrane blocks passage of the second electrolytic ions.

8. The iontophoresis device according to claim 7, further comprising a second ion-exchange membrane for selectively passing the ions of the first polarity, the second ion-exchange membrane being placed on a front side of the drug solution holding part.

9. An iontophoresis device for administering drug ions to a living body, comprising:

an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved;

a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part; and

a first ion-exchange membrane for selectively passing ions of the second polarity, the first ion-exchange membrane being placed between the electrolyte solution holding part and the drug solution holding part,

wherein the first ion-exchange membrane blocks passage of one of the electrolyte molecules and the first electrolytic ions.

10. The iontophoresis device according to claim 9, further comprising a second ion-exchange membrane for selectively passing the ions of the first polarity, the second ion-exchange membrane being placed on a front side of the drug solution holding part.

11. An iontophoresis device for administering drug ions to a living body, comprising:

an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved;

a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part; and

a first ion-exchange membrane for selectively passing ions of the second polarity, the first ion-exchange membrane being placed between the electrolyte solution holding part and the drug solution holding part,

wherein the first ion-exchange membrane blocks passage of one of the drug molecules and the drug ions.

12. The iontophoresis device according to claim 11, further comprising a second ion-exchange membrane for selectively passing the ions of the first polarity, the second ion-exchange membrane being placed on a front side of the drug solution holding part.