Two-stage scar generation for treating atrial fibrillation
First Claim
1. A method of creating a conduction block in tissue comprising:
- placing an implant in a target location in a patient, said target location having a wall thickness;
inducing a first scar through at least a portion of said wall thickness using a first scarring mechanism;
inducing a second scar through a remaining portion of said wall thickness using a second scarring mechanism; and
wherein said first scarring mechanism is different than said second scarring mechanism.
3 Assignments
0 Petitions
Accused Products
Abstract
The present invention seeks to provide an implant configured to utilize at least two different scar-generating mechanisms that are generated in sequential or overlapping stages. For example, in one embodiment the present invention provides an expandable device that can be positioned at a desired target location within a patient to generate mechanical ablation damage. After a predetermined amount of mechanical ablation has occurred, additional ablation damage is generated by a different source, such as energy delivery, drug delivery, or inflammatory material delivery. In this respect, the overall ablation scarring can be better controlled by utilizing the ablation techniques that are most appropriate at specific phases of a technique or locations within a patient.
-
Citations
45 Claims
-
1. A method of creating a conduction block in tissue comprising:
-
placing an implant in a target location in a patient, said target location having a wall thickness;
inducing a first scar through at least a portion of said wall thickness using a first scarring mechanism;
inducing a second scar through a remaining portion of said wall thickness using a second scarring mechanism; and
wherein said first scarring mechanism is different than said second scarring mechanism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 37)
-
-
14. A prosthesis for generating a scar within a patient comprising:
-
a prosthesis body having an expanded state and a compressed state;
a first ablation component disposed on said prosthesis so as to induce tissue ablation during a first period of time; and
a second ablation component disposed on said prosthesis so as to induce tissue ablation during a second period of time. - View Dependent Claims (15, 16, 17, 18, 19, 20, 38)
-
-
21. A method of creating a conduction block in tissue comprising:
-
placing an implant in a target location in a patient, said target location having a tissue thickness;
damaging at least a portion of said tissue thickness using a first ablating mechanism;
damaging a remaining portion of said tissue thickness using a second ablating mechanism; and
wherein said first ablating mechanism is different than said second ablating mechanism. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 39)
-
-
32. A method of creating a conduction block in tissue comprising:
-
placing an implant in a target location in a patient, said target location having a wall thickness;
reducing said wall thickness with a first tissue disruption mechanism of said implant;
damaging a remaining thickness of said target location with a second tissue disruption mechanism; and
wherein a tissue disruption capability of said second tissue disruption mechanism is inversely related to a tissue disruption capability of said first disruption mechanism. - View Dependent Claims (33, 34, 35, 36)
-
-
40. A method of creating scar lines through the wall of tissue of a pulmonary vein comprising:
-
providing a prosthesis having an expanded state and a compressed state;
pressing a portion of said prosthesis into tissue around an ostium of said pulmonary vein when said prosthesis is in its expanded state;
allowing a neointimal layer to substantially cover said portion of said prosthesis; and
releasing a substantial portion of an ablative material disposed in said portion of said prosthesis only after a formation of said neointimal layer. - View Dependent Claims (41, 42)
-
-
43. A device for creating scar lines through a tissue wall of a pulmonary vein comprising:
-
a support structure having an expanded state and a compressed state;
a tissue engagement structure disposed on said support structure;
said tissue engagement structure being loaded with an ablative material; and
said tissue engagement structure having a barrier structure preventing release of a substantial portion of said ablative material until after a neointimal layer is formed on said tissue engagement structure. - View Dependent Claims (44, 45)
-
Specification