Aneurysm treatment devices and methods

• US 20060116709A1
• Filed: 11/26/2004
• Published: 06/01/2006
• Est. Priority Date: 11/26/2004
• Status: Abandoned Application

• Current Assignee: Biomerix Corp.
• Original Assignee: Biomerix Corp.
• Inventors: Sepetka, Ivan, Aboytes, Maria, Jordan, Maybelle, Friedman, Craig F.
• Application Number:
  US10/998,357
• Publication Number:
  US 20060116709A1
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12163 having a string of elements connected to each other
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 2017/00862 elastic or resilient for sutures A61B2017/0618
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 2017/12095 Threaded connection
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers

Abstract

An aneurysm treatment device for in situ treatment of aneurysms comprises a collapsible member having a first shape wherein the first shape is an expanded geometric configuration, and a second shape, wherein the second shape is a collapsed configuration that is loadable into a catheter. The aneurysm treatment device is capable of returning to the first shape in the sac of an aneurysm upon deployment, where it occludes the aneurysm.

Claims

1. A occlusion device comprising:

a cylindrical compressible elastomeric matrix member having a proximal end and a distal end and having a lumen extending therethrough;

one or more compression members arranged in the compressible elastomeric matrix member to define one or more cylindrical sections;

a distal spring coil attached to the distal end of the compressible elastomeric matrix member; and

a proximal spring coil attached to the proximal end of the compressible elastomeric matrix member, wherein the device assumes a non-linear shape.

2. The device of claim 1, wherein the compressible elastomeric matrix is a biodurable, reticulated elastomeric matrix.

3. The device of claim 1, wherein the matrix is a polycarbonate polyurethane-urea, polycarbonate polyurea-urethane, polycarbonate polyurethane, or polycarbonate polysiloxane polyurethane.

4. The device of claim 1, wherein the matrix is resiliently recoverable.

5. The device of claim 1, wherein the lumen in the reticulated elastomeric matrix member comprises a flexible mesh lining.

6. The device of claim 5, wherein the mesh lining comprises a shape memory alloy or polymer.

7. The device of claim 5, wherein the mesh lining extends distally to form a jacket around the distal coil and extends proximally to form a jacket around the proximal coil.

8. The device of claim 1, wherein the proximal and distal coils each comprise a lumen in communication with the foam member lumen and capable of receiving a wire.

9. The device of claim 1, wherein the proximal coil has a retaining member.

10. The device of claim 1, wherein the proximal coil, the distal coil, or both comprise a shape memory alloy or polymer.

11. The device of claim 6 or 10, wherein the shape memory material is nitinol.

12. The device of claim 1 which is useful for occluding an aneurysm.

13. The device of claim 12, wherein the aneurysm is a cerebral aneurysm.

14. The device of claim 1 which is useful for occluding a vessel.

15. A system for occluding a vessel or aneurysm comprising:

an occlusion device of claim 1;

a delivery catheter having proximal and distal ends and surrounding the compressible elastomeric matrix member and compressing the compressible elastomeric matrix member therein;

a pushing catheter slidably positioned in the proximal end of the delivery catheter and having a proximal end and a distal end; and

a wire having proximal and distal ends and slidably positioned within the proximal end of the pushing catheter and extending into the distal coil of the compressible elastomeric matrix member of the occlusion device,

wherein the distal end of the pushing catheter has an opening, the distal coil of the compressible elastomeric matrix member has a retaining member attached thereto, and the retaining member extends through said opening to engage the wire.

16. The system of claim 15, wherein the distal end of each of the delivery catheter and the pushing catheter has a radiopaque marker.

17. The system of claim 15, wherein the distal coil of the compressible elastomeric matrix member has a distal end to receive the distal end of the wire.

43. A method of occluding an aneurysm or vessel which comprises deploying or inserting a device of claim 1, 18, 28, 31, 34, 37, and 40 into an aneurysm or vessel in a compressed state and allowing the device to expand.

18. An occlusion device comprising:

a flexible cylindrical structure having a external compressible elastomeric matrix surface, and

internal means to cause the flexible structure to expand in a radial direction to form a substantially spherical shape.

19. The device of claim 18, wherein the compressible elastomeric matrix is porous.

20. The device of claim 18, wherein the internal means comprises a coil or threaded structure that is capable of engaging an external member with reciprocal structure.

21. The device of claim 18 which is useful for occluding an aneurysm.

22. The device of claim 21, wherein the aneurysm is a cerebral aneurysm.

23. The device of claim 18 which is useful for occluding a vessel.

24. A system for occluding a vessel or aneurysm, comprising

a delivery catheter having a longitudinally extending lumen and proximal and distal ends;

an occlusion device of claim 18 positioned adjacent to distal end of the delivery catheter;

a longitudinal member extending through the lumen of the delivery catheter at the lumen of the occlusion device, said longitudinal member has a lumen extending therethrough and a distal section comprising structure that engages the internal means of the occlusion device.

25. The system of claim 24 which also comprises a guidewire that extends through the lumen of the longitudinal member.

26. The system of claim 24, wherein the distal section of the longitudinal member comprises a cylindrical section that extends distal to the occlusion device.

27. The system of claim 24, wherein the internal means of the occlusion device comprises coils that engage coils on the distal section of the longitudinal member to cause the occlusion device to assume a spherical shape.

28. An occlusion device which comprises a longitudinal compressible elastomeric matrix member having one or more radiopaque markers that define two or more sections of the reticulated elastomeric matrix member in the longitudinal direction, wherein a flexible suture or wire extends longitudinally through the reticulated elastomeric matrix member.

29. The device of claim 28, wherein the compressible elastomeric matrix is a biodurable, reticulated elastomeric matrix.

30. The device of claim 29, wherein the matrix is a polycarbonate polyurethane-urea, polycarbonate polyurea-urethane, polycarbonate polyurethane, or polycarbonate polysiloxane polyurethane.

31. An occlusion device which comprises a multitude of longitudinally extending compressible elastomeric matrix members that are intertwined and have one or more radiopaque markers that define sections of the device in the longitudinal direction.

32. The device of claim 31, wherein the compressible elastomeric matrix is a biodurable, reticulated elastomeric matrix.

33. The device of claim 32, wherein the matrix is a polycarbonate polyurethane-urea, polycarbonate polyurea-urethane, polycarbonate polyurethane, or polycarbonate polysiloxane polyurethane.

34. An occlusion device which comprises a square or rectangular essentially flat compressible elastomeric matrix member that has sutures and/or radiopaque markers extending along the edges thereof and/or diagonally.

35. The device of claim 34, wherein the compressible elastomeric matrix is a biodurable, reticulated elastomeric matrix.

36. The device of claim 35, wherein the matrix is a polycarbonate polyurethane-urea, polycarbonate polyurea-urethane, polycarbonate polyurethane, or polycarbonate polysiloxane polyurethane.

37. An occlusion device which comprises a wire structure covered by compressible elastomeric matrix wherein the wire structure comprises regularly spaced sections that are attached at a single point and the structure compresses to an essentially flat structure but expands to a regularly spaced structure when pressure is released.

38. The device of claim 37, wherein the compressible elastomeric matrix is a biodurable, reticulated elastomeric matrix.

39. The device of claim 38, wherein the matrix is a polycarbonate polyurethane-urea, polycarbonate polyurea-urethane, polycarbonate polyurethane, or polycarbonate polysiloxane polyurethane.

40. An occlusion device which comprises a cylindrically shaped wire structure comprising compressible elastomeric matrix and having lateral slots.

41. The device of claim 40, wherein the compressible elastomeric matrix is a biodurable, reticulated elastomeric matrix.

42. The device of claim 41, wherein the matrix is a polycarbonate polyurethane-urea, polycarbonate polyurea-urethane, polycarbonate polyurethane, or polycarbonate polysiloxane polyurethane.