Methods and compositions for treating a disease condition in a subject

• US 20060116721A1
• Filed: 10/14/2005
• Published: 06/01/2006
• Est. Priority Date: 10/15/2004
• Status: Active Grant

• Current Assignee: Palo Alto Investors
• Original Assignee: Palo Alto Investors
• Inventors: Lee, Patrick Yuarn-Bor, Yun, Anthony Joonkyoo
• Granted Patent: US 8,691,877 B2
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61K 31/395 having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• CPC Class Codes: A61K 31/4168 having a nitrogen attached in position 2, e.g. clonidine
• CPC Class Codes: A61K 31/4188 condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
• CPC Class Codes: A61K 31/475 having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine vincamine A61K31/4375
• CPC Class Codes: A61M 2205/054 with electrotherapy
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/18 Applying electric currents by contact electrodes
• CPC Class Codes: A61N 1/36002 Cancer treatment, e.g. tumour
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61P 9/12 Antihypertensives

Abstract

Methods for treating a disease condition in a subject are provided. The subject methods are characterizing by enhancing at least one symptom of the disease condition in a manner effective to cause the subject to mount a compensatory response effective to treat the disease condition. Also provided are compositions, kits and systems for practicing the subject methods.

Claims

1. A method of treating a subject for a disease condition, said method comprising:

enhancing at least one symptom of said disease condition in a manner effective to cause said subject to mount a compensatory response effective to treat said disease condition.

2. The method according to claim 1, wherein said enhancing comprises applying a stimulus to said subject.

3. The method according to claim 2, wherein said stimulus is a pharmacological agent.

4. The method according to claim 2, wherein said stimulus is an electrical stimulus.

5. The method according to claim 1, wherein said disease condition is a manifestation of an irregularity in a homeostatic pathway.

6. The method according to claim 5, wherein said disease condition is manifested by chronic sympathetic bias.

7. The method according to claim 6, wherein said disease condition is a cardiovascular disease.

8. The method according to claim 7, wherein said cardiovascular disease is hypertension.

9. The method according to claim 7, wherein said stimulus is a pharmacological agent.

10. The method according to claim 9, wherein said pharmacological agent is an adrenergic agonist.

11. The method according to claim 1, wherein said disease condition is a neurological condition.

12. The method according to claim 11, wherein said neurological condition is depression.

13. The method according to claim 12, wherein said agent is a serotonin antagonist.

14. The method according to claim 1, wherein said disease condition is an immune condition.

15. The method according to claim 14, wherein said immune condition is asthma.

16. The method according to claim 15, wherein said agent is a proinflammatory agent.

17. The method according to claim 1, wherein said disease condition is an endocrine system condition.

18. The method according to claim 17, wherein said disease condition is diabetes.

19. The method according to claim 18, wherein said agent is an insulin blocker.

20. The method according to claim 1, wherein said administering is of limited temporal duration.

21. The method according to claim 1, wherein said method comprises monitoring said subject.

22. The method according to claim 21, wherein said method comprises applying a first stimulus to said subject and monitoring said subject for a response thereto;

and applying a second stimulus to said subject, wherein said second stimulus is determined based on said monitored response to said first stimulus.

23. The method according to claim 22, wherein said first stimulus is a pharmacological agent.

24. The method according to claim 22, wherein said first stimulus is electrical energy.

25. An algorithm recorded on a computer-readable medium for administering a stimulus to said subject in accordance with method of claim 2.

26. A system comprising:

an algorithm recorded on a computer-readable medium for administering a stimulus to a subject according to a method of claim 2;

and a stimulus producing component.

27. The system according to claim 26, wherein said stimulus producing component is a pharmacological agent delivery device.

28. The system according to claim 27, wherein said stimulus producing component is an electrical energy applying device.

29. A kit comprising:

a stimulus producing component; and

instructions for a stimulus to a subject according to the method of claim 2.

30. The kit according to claim 29, wherein said stimulus producing component is a pharmacological agent delivery device.

31. The kit according to claim 29, wherein said stimulus producing component is an electrical energy applying device.