METHOD AND APPARATUS FOR QUANTIFICATION OF CARDIAC WALL MOTION ASYNCHRONY
First Claim
1. A system, comprising:
- a controller including;
a therapy protocol synthesizer adapted to generate a sequence of therapy parameters; and
an automatic therapy protocol execution module adapted to time delivery of a sequence of therapies each using at least one parameter of the sequence of therapy parameters;
a therapy circuit, coupled to the controller, to deliver the sequence of therapies; and
a cardiac wall motion evaluation module adapted to determine degrees of cardiac wall motion asynchrony each based on a portion of an echocardiogram recorded during the delivery of one therapy of the sequence of therapies.
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Abstract
A phase analysis technique provides for quantification of regional wall motion asynchrony from endocardial border contours generated from two-dimensional echocardiographic ventricular images. The technique produces results including a degree of radial ventricular asynchrony in heart failure patients with ventricular conduction delay to predict a magnitude of contractile function improvement with pacing therapy. Quantification of change in ventricular regional wall motion asynchrony in response to a therapy provides for a means to identify candidates to receive the therapy and quantitatively predict the benefit of the therapy. Quantification of changes in ventricular regional wall motion asynchrony in response to a sequence of therapies provides for a means to determine an approximately optimal therapy for an intended patient response.
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Citations
34 Claims
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1. A system, comprising:
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a controller including;
a therapy protocol synthesizer adapted to generate a sequence of therapy parameters; and
an automatic therapy protocol execution module adapted to time delivery of a sequence of therapies each using at least one parameter of the sequence of therapy parameters;
a therapy circuit, coupled to the controller, to deliver the sequence of therapies; and
a cardiac wall motion evaluation module adapted to determine degrees of cardiac wall motion asynchrony each based on a portion of an echocardiogram recorded during the delivery of one therapy of the sequence of therapies. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method, comprising:
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delivering a sequence of therapies;
recording an echocardiogram during the delivery of the sequence of therapies;
computing degrees of ventricular asynchrony each associated with one therapy of the sequence of therapies based on a portion of the echocardiogram recorded during the delivery of the one therapy of the sequence of therapies; and
determining an approximately optimal therapy based on the computed degrees of ventricular asynchrony. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification