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Suppression of endogenous immunoglobulin expression

  • US 20060117398A1
  • Filed: 10/21/2005
  • Published: 06/01/2006
  • Est. Priority Date: 10/22/2004
  • Status: Abandoned Application
First Claim
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1. A method for selective suppression of endogenous immunoglobulin production in B-cells of a non-human transgenic animal carrying an exogenous immunoglobulin translocus, comprising selectively expressing at least one suicide gene in B-cells producing an endogenous immunoglobulin of said non-human transgenic animal, but not in B cells producing an exogenous immunoglobulin, whereby B cells producing the endogenous immunoglobulin are depleted, and production of the endogenous immunoglobulin is suppressed, without suppressing the production of said exogenous immunoglobulin.

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