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Modulation of antibody specificity by tailoring the affinity to cognate antigens

  • US 20060121042A1
  • Filed: 10/27/2005
  • Published: 06/08/2006
  • Est. Priority Date: 10/27/2004
  • Status: Abandoned Application
First Claim
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1. A method of tailoring the specificity of a pan-specific antibody that specifically binds at least two members within a receptor tyrosine kinase (RTK) family, said method comprising randomizing each amino acid of the CDRs of said pan-specific antibody;

  • generating a library comprising said randomized CDRs; and

    screening said library for clones with altered affinity for a desired receptor(s).

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