Optical contrast agents for optically modifying incident radiation
First Claim
Patent Images
1. A method of forming an image of a sample, comprising:
- forming an image of a mixture, by exposing the mixture to electromagnetic radiation;
wherein the mixture comprises the sample and microparticles, the microparticles further comprise a surface coat, and the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.
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Abstract
A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and microparticles. The enhancement is particularly suitable for optical coherence tomography.
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Citations
42 Claims
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1. A method of forming an image of a sample, comprising:
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forming an image of a mixture, by exposing the mixture to electromagnetic radiation;
wherein the mixture comprises the sample and microparticles, the microparticles further comprise a surface coat, and the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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2. (canceled)
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16-30. -30. (canceled)
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31. In a method of forming an image by optical coherence tomography, including exposing a patient to electromagnetic radiation, collecting reflected electromagnetic radiation, and forming an image from the collected electromagnetic radiation, the improvement comprising administering a contrast agent to the patient to enhance contrast of the image,
wherein the contrast agent comprises microparticles comprising a surface coat, and the microparticles comprise cross-linked protein.
- 33. (canceled)
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35. A method of forming an image of a sample, comprising:
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forming an image of a mixture, by exposing the mixture to electromagnetic radiation;
wherein the mixture comprises the sample and microparticles, the microparticles further comprise a surface coat, the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light, the forming of the image is by optical coherence tomography, and the surface coat comprises polyethylene glycol. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42)
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Specification