Compositions and methods for attenuating mitochondria-mediated cell injury
First Claim
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1. A S-nitrosated mitochondria-targeted thiol antioxidant prodrug.
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Abstract
The present invention relates to a S-nitrosated mitochondria-targeted thiol-based antioxidant prodrug and uses therefore for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. When activated, prodrug of the present invention can specifically provide a NO• donor and a thiol-based antioxidant to mitochondria thereby decreasing the degree of mitochondrial dysfunction.
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5 Claims
- 1. A S-nitrosated mitochondria-targeted thiol antioxidant prodrug.
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