Tissue Engineered Stents
First Claim
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1. A method for producing a tissue engineered stent comprising the steps of:
- (a) providing a substrate shaped to form a substantially cylindrical construct, the substrate comprising a biodegradable polymer;
(b) contacting said substrate with dissociated chondrocytes capable of adhering thereto and forming cartilage, thereby forming a cell-seeded construct;
(c) maintaining said cell-seeded construct for a growth period in a fluid media suitable for growth of said chondrocytes to form a tissue-engineered stent, wherein the stent is designed to be implanted for the treatment of stricture diseases involving urethra, ureters, blood vessels, biliary ducts, intestines, airways of the lungs and fallopian tubes.
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Abstract
This invention is directed to a tissue-engineered stent comprising a substantially cylindrical construct (10) having a first end (12) and a second end (14); a walled surface (16) disposed between the first end and the second end; the walled surface (16) comprising a biodegradable polymer scaffold seeded with disassociated chondrocytes. In one embodiment, the seeded scaffold is cultured in vitro prior to implantation in a host for a time period sufficient for cartilaginous tissue to form.
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Citations
11 Claims
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1. A method for producing a tissue engineered stent comprising the steps of:
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(a) providing a substrate shaped to form a substantially cylindrical construct, the substrate comprising a biodegradable polymer;
(b) contacting said substrate with dissociated chondrocytes capable of adhering thereto and forming cartilage, thereby forming a cell-seeded construct;
(c) maintaining said cell-seeded construct for a growth period in a fluid media suitable for growth of said chondrocytes to form a tissue-engineered stent, wherein the stent is designed to be implanted for the treatment of stricture diseases involving urethra, ureters, blood vessels, biliary ducts, intestines, airways of the lungs and fallopian tubes. - View Dependent Claims (2, 3, 6)
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4. A method for producing a tissue engineered stent comprising the steps of:
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a. providing a substrate shaped to form a substantially cylindrical construct, the substrate comprising a biodegradable polymer;
b. contacting said substrate with dissociated chondrocytes expanded in vitro, and capable of adhering thereto and forming cartilage, thereby forming a cell-seeded construct;
c. maintaining said cell-seeded construct for a growth period in a fluid media suitable for growth of said chondrocytes to form a tissue-engineered stent, wherein the stent is designed to be implanted for the treatment of stricture diseases involving urethra, ureters, blood vessels, biliary ducts, intestines, airways of the lungs and fallopian tubes. - View Dependent Claims (5, 7)
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8. A tissue engineered stent comprising a substantially cylindrical construct having a first end and second end;
- a walled surface disposed between the first end and the second end, wherein the walled surface comprises a biodegradable polymer scaffold seeded with disassociated chondrocytes, wherein the stent is designed to be implanted for the treatment of stricture diseases involving urethra, ureters, blood vessels, biliary ducts, intestines, airways of the lungs and fallopian tubes.
- View Dependent Claims (9, 10, 11)
Specification