System and method for augmenting a humoral immune response

• US 20060122784A1
• Filed: 12/03/2004
• Published: 06/08/2006
• Est. Priority Date: 12/03/2004
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Ishikawa, Muriel Y., Myhrvold, Nathan P., Wood, Lowell L. Jr., Jung, Edward K.Y., Wilson, Richa
• Application Number:
  US11/004,446
• Publication Number:
  US 20060122784A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/02 Bacterial antigens
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present application relates, in general, to a system and/or method for detection and/or treatment.

Claims

1. A method, comprising:

identifying an association of at least a computable portion of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to the at least a computable portion of the one or more agents; and

selecting one or more immune response components in response to the projecting.

2. The method of claim 1, wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

3. The method of claim 1, wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

4. The method of claim 1, wherein the selecting one or more immune response components further comprises:

selecting at least a part of at least one B lymphocyte.

5. The method of claim 1, wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one B-lymphocyte.

6. The method of claim 1, wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

7. The method of claim 1, wherein the selecting one or more immune response components further comprises:

selecting one or more of a modulator of at least a part of at least one of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

8. The method of claim 1, wherein the identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

identifying an association of at least a computable portion of at least one of an organism, a virus, a dependent virus, an associated virus, a bacterium, a yeast, a mold, a fungus, a protoctist, an archaea, a mycoplasma, a phage, a mycobacterium, an ureaplasma, a chlamydia, a rickettsia, a nanobacterium, a prion, an agent responsible for transmissible spongiform encephelopathy (TSE), a multicellular parasite, a protein, an infectious protein, a polypeptide, a polyribonucleotide, a polydeoxyribonucleotide, a polyglycopeptide, a polysaccharide, a nucleic acid, an infectious nucleic acid, a polymeric nucleic acid, a metabolic byproduct, a cellular byproduct, or a toxin.

9. A system, comprising:

circuitry for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response;

circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of the one or more agents; and

circuitry for selecting one or more immune response components responsive to said circuitry for projecting.

10. The system of claim 9, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of one or more of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

11. The system of claim 9, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more modulators of at least a part of at least one of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

12. The system of claim 9, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of at least one B lymphocyte.

13. The system of claim 9, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more of modulators of at least a part of at least one B-lymphocyte.

14. The system of claim 9, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of one or more of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

15. The system of claim 9, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more of a modulator of at least a part of at least one of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

16. The system of claim 9, wherein the circuitry for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

circuitry for identifying an association of at least a portion of at least one of an organism, a virus, a dependent virus, an associated virus, a bacterium, a yeast, a mold, a fungus, a protoctist, an archaea, a mycoplasma, a phage, a mycobacterium, an ureaplasma, a chlamydia, a rickettsia, a nanobacterium, a prion, an agent responsible for transmissible spongiform encephelopathy (TSE), a multicellular parasite, a protein, an infectious protein, a polypeptide, a polyribonucleotide, a polydeoxyribonucleotide, a polyglycopeptide, a polysaccharide, a nucleic acid, an infectious nucleic acid, a polymeric nucleic acid, a metabolic byproduct, a cellular byproduct, or a toxin.

17. A method, comprising:

accepting an input of one or more agents; and

identifying an association of at least a computable portion of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

18. A system, comprising:

circuitry for accepting an input of one or more agents; and

circuitry for identifying an association of at least one computable portion of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

19. A method, comprising:

projecting a pattern of one or more changes relating to at least a computable portion of one or more agents; and

selecting one or more immune response components in response to said projecting.

20. A system, comprising:

circuitry for projecting a pattern of one or more changes relating to at least one computable portion of one or more agents; and

circuitry for selecting one or more immune response components in response to said projecting.

21. A method, comprising:

identifying an association of at least one computable epitope of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to the at least one computable epitope of the one or more agents; and

selecting one or more immune response components in response to the projecting.

22. The method of claim 21, wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

23. The method of claim 21, wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

24. The method of claim 21, wherein the selecting one or more immune response components further comprises:

selecting at least a part of at least one B lymphocyte.

25. The method of claim 21, wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one B-lymphocyte.

26. The method of claim 21, wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

27. The method of claim 21, wherein the selecting one or more immune response components further comprises:

selecting one or more of a modulator of at least a part of at least one of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

28. The method of claim 21, wherein the identifying an association of at least one computable epitope of one or more agents with a part of an immune response further comprises:

identifying an association of at least one computable epitope of at least one of an organism, a virus, a dependent virus, an associated virus, a bacterium, a yeast, a mold, a fungus, a protoctist, an archaea, a mycoplasma, a phage, a mycobacterium, an ureaplasma, a chlamydia, a rickettsia, a nanobacterium, a prion, an agent responsible for transmissible spongiform encephalopathy (TSE), a multicellular parasite, a protein, an infectious protein, a polypeptide, a polyribonucleotide, a polydeoxyribonucleotide, a polyglycopeptide, a polysaccharide, a nucleic acid, an infectious nucleic acid, a polymeric nucleic acid, a metabolic byproduct, a cellular byproduct, or a toxin.

29. A system, comprising:

circuitry for identifying an association of at least one computable epitope of one or more agents with at least a part of an immune response;

circuitry for projecting a pattern of one or more changes relating to the at least one computable epitope of the one or more agents; and

circuitry for selecting one or more immune response components in response to the projecting.

30. The system of claim 29, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of one or more of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

31. The system of claim 29, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more modulators of at least a part of at least one of a macrophage, a neutrophil, a cytotoxic cell, a lymphocyte, a T-lymphocyte, a killer T-lymphocyte, an immune response modulator, a helper T-lymphocyte, an antigen receptor, an antigen-presenting cell, a dendritic cell, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a cluster differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

32. The system of claim 29, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of at least one B lymphocyte.

33. The system of claim 29, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more modulators of at least a part of at least one B-lymphocyte.

34. The system of claim 29, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of one or more of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

35. The system of claim 29, wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more of a modulator of at least a part of at least one of an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a diabody, a chimeric antibody, a humanized antibody, a human antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, an anti-idiotypic antibody, or an antibody fragment.

36. The system of claim 29, wherein the circuitry for identifying an association of at least one computable epitope of one or more agents with a part of an immune response further comprises:

circuitry for identifying an association of at least one computable epitope of at least one of an organism, a virus, a dependent virus, an associated virus, a bacterium, a yeast, a mold, a fungus, a protoctist, an archaea, a mycoplasma, a phage, a mycobacterium, an ureaplasma, a chlamydia, a rickettsia, a nanobacterium, a prion, an agent responsible for a transmissible spongiform encephalopathy (TSE), a multicellular parasite, a protein, an infectious protein, a polypeptide, a polyribonucleotide, a polydeoxyribonucleotide, a polyglycopeptide, a polysaccharide, a nucleic acid, an infectious nucleic acid, a polymeric nucleic acid, a metabolic byproduct, a cellular byproduct, or a toxin.

37. A method, comprising:

accepting an input of one or more agents; and

identifying an association of at least one computable epitope of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

38. A system, comprising:

circuitry for accepting an input of one or more agents; and

circuitry for identifying an association of at least one computable epitope of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

39. A method, comprising:

projecting a pattern of one or more changes relating to at least one computable epitope of one or more agents; and

selecting one or more immune response components in response to said projecting.

40. A system, comprising:

circuitry for projecting a pattern of one or more changes relating to at least one computable epitope of one or more agents; and

circuitry for selecting one or more immune response components in response to said projecting.

41. A method, comprising:

identifying an association of at least one antigen of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to at least one antigen of the one or more agents; and

selecting one or more immune response components in response to the projecting.

42. A system, comprising:

circuitry for identifying an association of at least one antigen of one or more agents with at least a part of an immune response;

circuitry for projecting a pattern of one or more changes relating to the at least one antigen of the one or more agents; and

circuitry for selecting one or more immune response components responsive to said circuitry for projecting.

43. A method, comprising:

accepting an input of one or more agents; and

identifying an association of at least one antigen of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

44. A system, comprising:

circuitry for accepting an input of one or more agents; and

circuitry for identifying an association of at least one antigen of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

45. A method, comprising:

projecting a pattern of one or more changes relating to at least one antigen of one or more agents; and

selecting one or more immune response components in response to said projecting.

46. A system, comprising:

circuitry for projecting a pattern of one or more changes relating to at least one antigen of one or more agents; and

circuitry for selecting one or more immune response components in response to said projecting.

47. A method, comprising:

identifying an association of at least one epitope of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to the at least one epitope of the one or more agents; and

selecting one or more immune response components in response to the projecting.

48. A system, comprising:

circuitry for associating at least one epitope of one or more agents with at least a part of an immune response;

circuitry for projecting a pattern of one or more changes relating to the at least one epitope of the one or more agents; and

circuitry for selecting one or more immune response components responsive to said circuitry for projecting.

49. A method, comprising:

accepting an input of one or more agents; and

identifying an association of at least one epitope of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

50. A system, comprising:

circuitry for accepting an input of one or more agents; and

circuitry for identifying an association of at least one epitope of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

51. A method, comprising:

projecting a pattern of one or more changes relating to at least one epitope of one or more agents; and

selecting one or more immune response components in response to said projecting.

52. A system, comprising:

circuitry for projecting a pattern of one or more changes relating to at least one epitope of one or more agents; and

circuitry for selecting one or more immune response components in response to said projecting.

53. A method, comprising:

identifying an association of at least one computable antigen of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to the at least one computable antigen of the one or more agents; and

selecting one or more immune response components in response to the projecting.

54. A system, comprising:

circuitry for associating at least one computable antigen of one or more agents with at least a part of an immune response;

circuitry for projecting a pattern of one or more changes relating to the at least one computable antigen of the one or more agents; and

circuitry for selecting one or more immune response components responsive to said circuitry for projecting.

55. A method, comprising:

accepting an input of one or more agents; and

identifying an association of at least one computable antigen of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

56. A system, comprising:

circuitry for accepting an input of one or more agents; and

circuitry for identifying an association of at least one computable antigen of one or more agents with at least a part of an immune response related to suppressing the one or more agents.

57. A method, comprising:

projecting a pattern of one or more changes relating to at least one computable antigen of one or more agents; and

selecting one or more immune response components in response to said projecting.

58. A system, comprising:

circuitry for projecting a pattern of one or more changes relating to at least one computable antigen of one or more agents; and

circuitry for selecting one or more immune response components in response to said projecting.