Microprocessors, devices, and methods for use in monitoring of physiological analytes

• US 20060127964A1
• Filed: 02/08/2006
• Published: 06/15/2006
• Est. Priority Date: 07/30/2004
• Status: Abandoned Application

• Current Assignee: Janet A. Tamada, Matthew J. Lesho, Michael J. Tierney, Russell Ford
• Original Assignee: Janet A. Tamada, Matthew J. Lesho, Michael J. Tierney, Russell Ford
• Inventors: Lesho, Matthew J., Tamada, Janet A., Tierney, Michael J., Ford, Russell
• Application Number:
  US11/350,193
• Publication Number:
  US 20060127964A1
• Time in Patent Office: Days
• US Class Current: 435/14
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4266 sweat secretion
• CPC Class Codes: A61B 5/4283 gastrointestinal secretions, e.g. bile production
• CPC Class Codes: A61B 5/4881 Determining interstitial fluid distribution or content within body tissue measuring analytes in interstitial fluid in-vivo A61B5/1451
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: G16H 40/63 for local operation

Abstract

Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.

Claims

1. An analyte monitoring device comprising,

(A) One or more collection reservoirs adapted for contact with a skin or mucosal surface of a subject, wherein (i) movement of said analyte into said collection reservoirs is enhanced by a transdermal or transmucosal sampling method, and (ii) during use of said device at least one collection device is placed in operative contact with an analyte sensing device;

and

(B) One or more collection reservoirs adapted for contact with a skin or mucosal surface of a subject, wherein (i) movement of said analyte into said collection reservoirs not enhanced by said transdermal or transmucosal sampling method, and (ii) during use of said device at least one collection device is placed in operative contact with an analyte sensing device.

2. The analyte monitoring device of claim 1, wherein during use of said device at least one collection reservoir of (B) is in contact with a thermistor.

3. The analyte monitoring device of claim 1, wherein the physical characteristics of at least one collection reservoir of (A) are substantially the same as the physical characteristics of at least one collection reservoir of (B).

4. The analyte monitoring device of claim 3, wherein the at least one collection reservoir of (A) comprises a hydrogel.

5. The analyte monitoring device of claim 1, wherein said analyte sensing device is a device that detects analyte electrochemically.

6. The analyte monitoring device of claim 5, wherein said analyte sensing device comprises a sensing electrode.

7. The analyte monitoring device of claim 6, wherein the physical characteristics of the sensing electrode in contact with at least one collection reservoir of (A) has substantially the same physical characteristics of the sensing electrode in contact with at least one collection reservoir of (B).

8. The analyte monitoring device of claim 6, wherein said analyte sensing device further comprises an enzyme to facilitate electrochemical detection of the analyte.

9. The analyte monitoring device of claim 8, wherein said analyte is glucose and said enzyme comprises glucose oxidase.

10. The analyte monitoring device of claim 6, further comprising iontophoretic electrodes in contact with said one or more collection reservoirs of (A).

11. The analyte monitoring device of claim 1, wherein a collection reservoir of (B) comprises first and second surfaces, said first surface is in contact with a sensing device and said second surface is in contact with a membrane substantially impermeable to analyte, and said membrane is adapted for contact with said skin or mucosal surface.