4'-thionucleotide

• US 20060127990A1
• Filed: 08/21/2003
• Published: 06/15/2006
• Est. Priority Date: 08/22/2002
• Status: Abandoned Application

• Current Assignee: GeneticLab Co., Ltd. (Eurofins Scientific SE)
• Original Assignee: Akira Matsuda, GeneticLab Co., Ltd. (Eurofins Scientific SE)
• Inventors: Matsuda, Akira, Minakawa, Noriaki, Kato, Yuka
• Application Number:
  US10/524,817
• Publication Number:
  US 20060127990A1
• Time in Patent Office: Days
• US Class Current: 435/91.200
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07H 19/067 with ribosyl as the saccharide radical
• CPC Class Codes: C07H 19/073 with 2-deoxyribosyl as the saccharide radical
• CPC Class Codes: C07H 19/167 with ribosyl as the saccharide radical
• CPC Class Codes: C07H 19/173 with 2-deoxyribosyl as the saccharide radical

Abstract

Disclosed is a compound of formula I:
[wherein B is a nucleobase selected from the group consisting of adenine, guanine, cytosine, uracil and hypoxanthine], a compound of formula II: [wherein B′ is a nucleobase selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and hypoxanthine], a method for synthesizing these nucleoside triphosphates, and a process for producing an oligonucleotide using these nucleoside triphosphates.

Claims

1. A compound of formula I:

5. A process for producing an oligonucleotide containing at least one nucleoside unit of formula VI:

2. A compound of formula II:

6. A process for producing an oligonucleotide containing at least one nucleotide unit of formula VII:

3. A method for synthesizing a compound of formula I:

4. A method for synthesizing a compound of formula II: