Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration
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Abstract
The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.
14 Citations
244 Claims
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1-203. -203. (canceled)
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204. A method comprising the step of:
providing to a consumer an EPO dosing regimen, wherein said regimen maintains at least a serum EPO concentration above a predose level for about 5 to 30 days. - View Dependent Claims (205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244)
Specification