Novel approach to antimicrobial host defense with molecular shields with EPA and DHA analogs
First Claim
1. A method for the stimulation of bactericidal permeability increasing protein (BPI) in a subject'"'"'s tissue, comprising the step of administering to a subject infected with BPI sensitive bacteria a therapeutically effective amount of a pharmaceutical composition comprising an eicosapentaenoic acid (EPA) analog and a pharmaceutically acceptable carrier, such that the subject'"'"'s tissues express increased levels of BPI to treat the BPI sensitive infection, wherein the EPA analog is selected from the group consisting of:
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Abstract
Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. Various BPI inducing agents include icosapentanoic acid (EPA) analogs and docosahexaenoic acid (DHA) analogs.
63 Citations
6 Claims
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1. A method for the stimulation of bactericidal permeability increasing protein (BPI) in a subject'"'"'s tissue, comprising the step of administering to a subject infected with BPI sensitive bacteria a therapeutically effective amount of a pharmaceutical composition comprising an eicosapentaenoic acid (EPA) analog and a pharmaceutically acceptable carrier, such that the subject'"'"'s tissues express increased levels of BPI to treat the BPI sensitive infection, wherein the EPA analog is selected from the group consisting of:
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2. A method for the simulation of bactericidal permeability increasing protein (BPI) in a subject'"'"'s tissue, comprising the step of administering to a subject infected with BPI sensitive bacteria a therapeutically effective amount of a pharmaceutical composition comprising a docosahexaenoic acid (DHA) analog and a pharmaceutically acceptable carrier, such that the subject'"'"'s tissues express increased levels of BPI to treat the BPI sensitive infection, wherein the DHA analog is selected from the group consisting of:
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3. A method for the stimulation of bactericidal permeability increasing protein (BPI) in mucosal cells, comprising the step of administering to a subject infected with BPI sensitive bacteria a therapeutically effective amount of pharmaceutical composition comprising an eicosapentaenoic acid (EPA) analog and a pharmaceutically acceptable carrier, such that the mucosal cells express increased levels of BPI to treat the BPI sensitive infection, wherein the EPA analog is selected from the group consisting of:
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4. A method for the stimulation of bactericidal permeability increasing protein (BPI) in mucosal cells, comprising the step of administering to a subject infected with BPI sensitive bacteria a therapeutically effective amount o f a pharmaceutical composition comprising a docosahexaenoic acid (DHA) analog and a pharmaceutically acceptable carrier, such that the mucosal cells express increased levels of BPI to treat the BPI sensitive infection, wherein the DHA analog is selected from the group consisting of:
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5. A method for treating a bacterial infection in a subject, comprising the step of administering to a subject infected with BPI sensitive bacteria a therapeutically effective amount of a pharmaceutical composition comprising an eicosapentaenoic acid (EPA) analog and a pharmaceutical carrier, such that infection by the BPI sensitive bacteria in a subject is treated, wherein the EPA analog is selected from the group consisting of:
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6. A method for treating a bacterial infection in subject, comprising the step of administering to a subject infected with BPI sensitive bacteria a therapeutically effective amount of a pharmaceutical composition comprising a docosahexaenoic acid (DHA) analog and a pharmaceutical carrier, such that infection by the BPI sensitive bacteria in a subject is treated, wherein the DHA analog is selected from the group consisting of:
Specification