Iontophoresis device

• US 20060129085A1
• Filed: 06/30/2005
• Published: 06/15/2006
• Est. Priority Date: 12/09/2004
• Status: Active Grant

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcutaneous Technologies, Inc.
• Inventors: Tanioka, Akihiko, Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Granted Patent: US 7,590,444 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane

Abstract

An iontophoresis device for administering drug ions via the first ion-exchange membrane, comprising a first semi-permeable film having a number of pores passing through the film from a front surface to a back surface, a first ion-exchange membrane formed of ion-exchange resin filling the pores of the first semi-permeable film and selective ions of a first polarity, and a working electrode structure having a drug holding part placed on a back surface of the first ion-exchange membrane and holding a drug solution containing drug ions charged in the first polarity, wherein a layer of a water-soluble polymer compound chemically bonded on the surface of the first semi-permeable film.

Claims

1. An iontophoresis device comprising a working electrode structure, comprising:

a first ion-exchange membrane including a first semi-permeable film with a number of pores communicating a front surface and a back surface of the first porous film and an ion-exchange resin filled in the pores of the first semi-permeable film, said first ion-exchange membrane selecting ions of a first polarity; and

a drug holding part placed on a back surface side of the first ion-exchange membrane and holding a drug solution containing drug ions charged in the first polarity,

the drug ions being administered via the first ion-exchange membrane,

wherein a first layer of a water-soluble polymer compound chemically bonded to a material constituting the first semi-permeable film is formed on the front surface of the first semi-permeable film.

2. The iontophoresis device according to claim 1, wherein the working electrode structure further comprises:

a first electrode supplied with a voltage potential of the first polarity;

a second electrolyte solution holding part for holding an electrolyte solution in electrical contact with the first electrode; and

a third ion-exchange membrane placed on a front surface side of the second electrolyte holding part and selecting ions of the second polarity,

wherein the drug holding part is placed on a front surface side of the third ion-exchange membrane, and

the first ion-exchange membrane is placed on a front surface side of the drug holding part.

3. The iontophoresis device according to claim 1, wherein a water-soluble polymer compound constituting one of the first layer and the second layer has a straight-chain structure, and is bonded to the front surface of one of the first semi-permeable film and the second semi-permeable film in a brush shape.

4. The iontophoresis device according to claim 1, wherein one of the first layer and the second layer is formed by irradiating one of the first semi-permeable film and the second semi-permeable film immersed in an aqueous solution in which a water-soluble polymer compound is dissolved, with a UV-ray, an electron beam, a y-ray, or plasma.

5. The iontophoresis device according to claim 1, wherein the water-soluble polymer compound forming one of the first layer and the second layer is one selected from the group consisting of:

polyvinyl alcohol;

poly-N-isopropylacrylamide;

polyacrylic acid;

poly-N-methylacrylamide;

polyacrylamide;

poly-N-methylacrylamide;

polyvinylpyrrolidone;

polymethacrylic acid;

polyethylene glycol;

polyethyleneimine;

poly-N-dimethylaminoethyl methacrylate; and

polypeptide;

or a mixture thereof.

6. The iontophoresis device according to claim 1, further comprising:

on the front surface of one of the first semi-permeable film and the second semi-permeable film, a third layer made of a water-soluble polymer compound laminated on one of the first layer and the second layer of the water-soluble polymer compound.

7. The iontophoresis device according to claim 6, wherein the water-soluble polymer compound forming the third layer is one selected from the group consisting of:

polyvinyl alcohol;

poly-N-isopropylacrylamide;

polyacrylic acid;

poly-N-methylacrylamide;

polyvinylpyrrolidone, polymethacrylic acid;

polyethylene glycol;

polyethyleneimine;

poly-N-dimethylaminoethyl methacrylate; and

polypeptide, or a mixture thereof.

8. The iontophoresis device according to claim 1, further comprising a nonworking electrode structure operating as a counterpart of the working electrode structure,

the nonworking electrode structure having:

a second ion-exchange membrane including a second semi-permeable film with a number of pores communicating a front surface and a back surface of the second semi-permeable film and an ion-exchange resin filled in the pores of the second semi-permeable film, said second ion-exchange membrane selecting ions of a second polarity opposite to the first polarity; and

a first electrolyte solution holding part for holding an electrolyte solution, placed on a back surface side of the second ion-exchange membrane,

wherein a second layer of a water-soluble polymer compound chemically bonded to a material constituting the second semi-permeable film is formed on the front surface of the second semi-permeable film.

9. The iontophoresis device according to claim 8, wherein the working electrode structure further comprises:

a first electrode supplied with a voltage potential of the first polarity;

a second electrolyte solution holding part for holding an electrolyte solution in electrical contact with the first electrode; and

a third ion-exchange membrane placed on a front surface side of the second electrolyte holding part and selecting ions of the second polarity,

wherein the drug holding part is placed on a front surface side of the third ion-exchange membrane, and

the first ion-exchange membrane is placed on a front surface side of the drug holding part.

10. The iontophoresis device according to claim 8, wherein a water-soluble polymer compound constituting one of the first layer and the second layer has a straight-chain structure, and is bonded to the front surface of one of the first semi-permeable film and the second semi-permeable film in a brush shape.

11. The iontophoresis device according to claim 8, wherein one of the first layer and the second layer is formed by irradiating one of the first semi-permeable film and the second semi-permeable film immersed in an aqueous solution in which a water-soluble polymer compound is dissolved, with a UV-ray, an electron beam, a y-ray, or plasma.

12. The iontophoresis device according to claim 8, wherein the water-soluble polymer compound forming one of the first layer and the second layer is one selected from the group consisting of:

polyvinyl alcohol;

poly-N-isopropylacrylamide;

polyacrylic acid;

poly-N-methylacrylamide;

polyacrylamide;

poly-N-methylacrylamide;

polyvinylpyrrolidone;

polymethacrylic acid;

polyethylene glycol;

polyethyleneimine;

poly-N-dimethylaminoethyl methacrylate; and

polypeptide;

or a mixture thereof.

13. The iontophoresis device according to claim 8, further comprising:

on the front surface of one of the first semi-permeable film and the second semi-permeable film, a third layer made of a water-soluble polymer compound laminated on one of the first layer and the second layer of the water-soluble polymer compound.

14. The iontophoresis device according to claim 13, wherein the water-soluble polymer compound forming the third layer is one selected from the group consisting of:

polyvinyl alcohol;

poly-N-isopropylacrylamide;

polyacrylic acid;

poly-N-methylacrylamide;

polyvinylpyrrolidone, polymethacrylic acid;

polyethylene glycol;

polyethyleneimine;

poly-N-dimethylaminoethyl methacrylate; and

polypeptide, or a mixture thereof.