Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium

• US 20060129225A1
• Filed: 12/15/2004
• Published: 06/15/2006
• Est. Priority Date: 12/15/2004
• Status: Abandoned Application

• Current Assignee: Wyeth (Pfizer Inc.)
• Original Assignee: Wyeth (Pfizer Inc.)
• Inventors: Llanos, Gerard, Kopia, Gregory A.
• Application Number:
  US11/013,081
• Publication Number:
  US 20060129225A1
• Time in Patent Office: Days
• US Class Current: 623/1.130
• CPC Class Codes: A61B 17/0644 penetrating the tissue, deformable to closed position
• CPC Class Codes: A61B 17/0686 having a forming anvil staying below the tissue during stapling
• CPC Class Codes: A61B 17/115 Staplers for performing anastomosis in a single operation
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/0641 having at least three legs as part of one single body
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0025 Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2220/0066 stapled
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/001 Figure-8-shaped, e.g. hourglass-shaped
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/00 : Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism'"'"'s reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism'"'"'s reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. Implantable medical devices may be coated or otherwise have affixed thereto agents for healing ischemic tissue.

Claims

1. A percutaneously delivered apparatus positionable in a vessel in proximity to a treatment site comprising:

a medical device;

one or more agents, in therapeutic dosages, for treating ischemic tissue and;

a delivery mechanism, comprising the one or more agents, operatively associated with the medical device and configured to deliver at least one agent to downstream ischemic tissue over a predetermined period of time.

2. The percutaneously delivered apparatus according to claim 1, wherein the medical devices comprises an intraluminal device.

3. The percutaneously delivered apparatus according to claim 2, wherein the intraluminal device comprises a stent.

4. The percutaneously delivered apparatus according to claim 3, wherein the intraluminal device comprises a stent-graft.

5. The percutaneously delivered apparatus according to claim 3, wherein the intraluminal device comprises an anastomosis device.

6. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises calcium antagonists.

7. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises organic nitrates.

8. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises beta-adrenoceptor blocking agents.

9. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises hormones.

10. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises potassium channel activators.

11. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises ACE inhibitors.

12. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises anti-inflammatory agents.

13. The percutaneously delivered apparatus according to claim 1, wherein the one or more agents comprises statins.

14. The percutaneously delivered apparatus according to claim 1, wherein one or more antiarrhythmic agents.

15. The percutaneously delivered apparatus according to claim 3, wherein the delivery mechanism comprises channels or openings in the stent.

16. The percutaneously delivered apparatus according to claim 3, wherein the delivery mechanism comprises a polymeric matrix, wherein the one or more agents are incorporated in the polymeric matrix and affixed to the stents.

17. A percutaneously delivered apparatus positioned in a vessel in proximity to a treatment site comprising:

a medical device;

one or more first agents, in therapeutic dosages, for treating ischemic tissue;

one or more second agents, in therapeutic dosages, for promoting tissue healing; and

a delivery mechanism, comprising the one or more first agents and the one or more second agents, operatively associated with the medical device and configured to deliver the at least one first agent and the at least second agent to downstream ischemic tissue over a predetermined period of time.