Investigating different physical and/or chemical forms of materials

• US 20060129329A1
• Filed: 11/15/2005
• Published: 06/15/2006
• Est. Priority Date: 04/09/2001
• Status: Abandoned Application

• Current Assignee: Millennium Pharmaceuticals Incorporated (Takeda Pharmaceutical Company Limited)
• Original Assignee: Millennium Pharmaceuticals Incorporated (Takeda Pharmaceutical Company Limited)
• Inventors: Stylianopoulos, Vassilis, Kobylecki, Ryszard Jurek, Cowell, Daniel
• Application Number:
  US11/280,980
• Publication Number:
  US 20060129329A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00286 Reactor vessels with top and bottom openings
• CPC Class Codes: B01J 2219/00364 Pipettes
• CPC Class Codes: B01J 2219/00423 using filtration, e.g. through porous frits
• CPC Class Codes: B01J 2219/00477 Means for pressurising the reaction vessels
• CPC Class Codes: B01J 2219/00481 by the use of moving stirrers within the reaction vessels
• CPC Class Codes: B01J 2219/00495 Means for heating or cooling the reaction vessels
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/00599 Solution-phase processes
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00689 using computers
• CPC Class Codes: B01J 2219/00691 using robots
• CPC Class Codes: B01J 2219/00695 Synthesis control routines, e.g. using computer programs
• CPC Class Codes: B01J 2219/00704 integrated with the reactor apparatus
• CPC Class Codes: B01J 2219/00756 Compositions, e.g. coatings, crystals, formulations
• CPC Class Codes: C40B 60/02 Integrated apparatus specially adapted for creating libraries, screening libraries and for identifying library members
• CPC Class Codes: G01N 35/028 having reaction cells in the form of microtitration plates

Abstract

A method is provided for investigating different physical and/or chemical forms of a material. The material is placed in an array of receptacles. The material in different receptacles is subjected to different treatments under the control of a computer. Any material resulting from the different treatments is then analyzed. The treatments and the resultant material may be suitably associated. An apparatus used in this method provides an array of receptacles into which the material may be placed. The apparatus includes means for treating the material in the receptacles, for example by heating with a heater block, cooling with a cooling coil, and agitation by a stirrer block. The apparatus includes a computer to control the respective different treatments to the material in the different receptacles. The receptacles may optionally include a porous member that is porous to fluids but not the initial material.

Claims

1. A method of investigating different physical and/or chemical forms of a material, the method comprising:

providing an array of receptacles each containing material (hereinafter “

said initial material”

) to be investigated;

subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer; and

analysing any material resulting from said different treatments (hereinafter “

said resultant material”

).

2. A method according to claim 1 which includes associating data relating to the analysis of each resultant material with information relating to the treatment(s) used to prepare said resultant material from said initial material.

3. A method according to claim 1, wherein data relating to said analysis is stored in said computer and associated with said information relating to the treatment.

4. A method according to claim 1, wherein said computer is programmed to determine treatments to which initial material in receptacles is to be subjected.

5. A method according to claim 4, wherein said computer determines treatments in dependence upon the results of the analysis of resultant material in a first series of experiments using said array.

6. Apparatus for investigating different physical and/or chemical forms of a material, the apparatus comprising:

an array of receptacles for containing material (hereinafter “

initial material”

) to be investigated;

treatment means for subjecting initial material to respective different treatments; and

a computer arranged to control the respective different treatments to which initial material is subjected.

7. Apparatus according to claim 6, wherein said receptacles include a porous member which is porous to fluids but not to said initial material, wherein said porous member defines a wall for supporting initial material.