Dermal drug delivery system
First Claim
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1. A mechanised brushing device, wherein the mechanism of the device is adapted to rotate a brush in contact with the skin of a patient, the device having abutment means for contact with the skin, the brush being movably located in relation to the abutment means to allow it to be introduced to the skin, travel of the brush being limited in relation to the abutment means such that pressure on the brush to contact the skin is limited to a predefined range.
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Abstract
A device for brushing the skin prior to applying a topical preparation of a drug enhances the permeability of the stratum corneum to the drug.
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36 Claims
- 1. A mechanised brushing device, wherein the mechanism of the device is adapted to rotate a brush in contact with the skin of a patient, the device having abutment means for contact with the skin, the brush being movably located in relation to the abutment means to allow it to be introduced to the skin, travel of the brush being limited in relation to the abutment means such that pressure on the brush to contact the skin is limited to a predefined range.
- 25. A method for the conditioning of skin to enhance transdermal delivery of drug, the method comprising continuous brushing for a period sufficient to reduce the barrier qualities of the stratum corneum.
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