Biosensor utilizing a resonator having a functionalized surface
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Abstract
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator'"'"'s frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator'"'"'s frequency response.
65 Citations
26 Claims
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1-24. -24. (canceled)
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25. A system comprising:
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layer of piezoelectric material, wherein the layer of piezoelectric material has at least one surface that is functionalized to bind with target molecules pair of electrodes coupled to the layer of piezoelectric material control circuitry configured to apply an excitation signal to the pair of electrodes and to determine a frequency response for the layer of piezoelectric material.
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26-30. -30. (canceled)
Specification