Drug to be introduced tooth or periodontal tissue and apparatus for introducing drug to tooth or periodontal tissue

• US 20060134016A1
• Filed: 11/21/2003
• Published: 06/22/2006
• Est. Priority Date: 11/22/2002
• Status: Abandoned Application

• Current Assignee: Katsuro Tachibana, Misako Nakashima
• Original Assignee: Katsuro Tachibana, Misako Nakashima
• Inventors: Tachibana, Katsuro, Nakashima, Misako
• Application Number:
  US10/535,696
• Publication Number:
  US 20060134016A1
• Time in Patent Office: Days
• US Class Current: 424/50
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0063 Periodont

Abstract

Disclosed are a medical material for use in therapeutic agent delivery to a tooth or periodontal tissue, and an agent delivery apparatus for delivering a therapeutic agent to a tooth or periodontal tissue, by means of ultrasonic energy with less damage to the tooth or periodontal tissue. The medical material comprises a mixture of microbubbles and a therapeutic agent consisting of at least one of a plasmid DNA and a drug with a therapeutic effect on a tooth or periodontal disease. The agent delivery apparatus comprises an ultrasonic transducer having a tip provided with a detachable ultrasonic emitter for emitting an ultrasonic wave to a target site of a tooth or periodontal tissue, and a medical-material ejecting device for supplying the medical material to the target site.

Claims

1. A medical material for use in therapeutic agent delivery to a tooth or periodontal tissue by means of ultrasonic energy, comprising a mixture of microbubbles and a therapeutic agent consisting of at least one of a plasmid DNA and a drug with a therapeutic effect on a tooth or periodontal disease.

2. The medical material as defined in claim 1, which contains said microbubbles in the range of 0.001 to 10%.

3. An agent delivery apparatus for delivering a therapeutic agent to a tooth or periodontal tissue, comprising an ultrasonic transducer having a tip provided with a detachable ultrasonic emitter for emitting an ultrasonic wave to a target site of a tooth or periodontal tissue, and a medical-material ejecting device for supplying to said target site the medical material as defined in claim 1.

4. The agent delivery apparatus as defined in claim 3, which further comprises a manual control unit including means for adjusting the frequency and intensity of the ultrasonic wave to be generated from said ultrasonic transducer, whereby either one of a plurality of oscillation directions in said ultrasonic emitter can be selected according to changes of said frequency.